Exercise-Induced Autophagy in Fatty Liver Disease.
Exercise-Induced Autophagy in Fatty Liver Disease.
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DOI：
10.1249/jes.0000000000000116
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发表时间：
2017-07
影响因子：
5.7
通讯作者：
Kim JS
中科院分区：
文献类型：
--
作者：
Chun SK;Lee S;Yang MJ;Leeuwenburgh C;Kim JS
肝脏脂肪变性每年都很普遍。自噬是线粒体质量控制和肝脏中脂质平衡不可或缺的一部分。目前还没有可用于减少肝脏脂肪变性的药物策略，但众所周知，运动可以改善慢性肝病，特别是非酒精性脂肪性肝病(NAFLD)的临床结果。最近的研究表明，运动可能通过增强自噬来改善NAFLD。我们提出了一个假设，即通过运动激活自噬可以改善非酒精性脂肪性肝病发病机制中潜在的细胞缺陷。
Hepatic steatosis prevails each year. Autophagy is integral in mitochondrial quality control and lipid homeostasis in the liver. No pharmacological strategies are currently available to reduce hepatic steatosis, but exercise has been known to improve clinical outcomes of chronic liver disease, particularly non-alcoholic fatty liver disease (NAFLD). Recent studies suggest that exercise may improve NAFLD through enhancing autophagy. We propose a hypothesis that activation of autophagy through exercise ameliorates cellular defects underlying the pathogenesis of nonalcoholic fatty liver disease