Relation between structure, function, and imaging in a three-dimensional model of the lung.
Relation between structure, function, and imaging in a three-dimensional model of the lung.
复制标题
肺部三维模型中结构、功能和成像之间的关系。
DOI：
10.1114/1.1557972
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发表时间：
2003
影响因子：
3.8
通讯作者：
Lutchen,KR
中科院分区：
文献类型：
--
作者：
Tgavalekos,NoraT;Venegas,JG;Suki,B;Lutchen,KR
先前的研究报道了预测肺部功能关系的形态测量模型。然而，这些模型在解剖学上并不明确。我们提出了三维气道树模型，将动态肺功能与结构变化联系起来，特别是当在特定解剖位置异质地施加收缩模式时。首先，我们预测了动态肺阻力和弹性（RLandEL）对潜在收缩模式的明确形式的敏感性。模拟表明，仅限于肺部单个区域（顶端、中部或底部）的严重且不均匀的外周气道收缩不会对从气道开口测量的整个肺部特性产生实质性改变。相反，当测量的 RL 和 EL 异常时，整个气道树可能发生显着（但不一定均匀）的收缩。我们还介绍了图像辅助建模的概念。这里，对通气异质性敏感的正电子发射断层扫描成像数据与 RL 和 EL 数据进行合成，以帮助确定哪些气道收缩条件可以与两个数据集一致。最终目标是个性化预测。 ©2003 生物医学工程学会.PAC2003: 8719Uv, 8710+e, 8758Fg
Previous studies have reported morphometric models to predict function relations in the lung. These models, however, are not anatomically explicit. We have advanced a three-dimensional airway tree model to relate dynamic lung function to alterations in structure, particularly when constriction patterns are imposed heterogeneously in specific anatomic locations. First, we predicted the sensitivity of dynamic lung resistance and elastanceRLandEL) to explicit forms of potential constriction patterns. Simulations show that severe and heterogeneous peripheral airway constriction confined to a single region in the lung (apex, mid, or base) will not produce substantial alterations in whole lung properties as measured from the airway opening. Conversely, when measuredRLandELare abnormal, it is likely that significant (but not necessarily homogeneous) constriction has occurred throughout the entire airway tree. We also introduce the concept of image-assisted modeling. Here positron emission tomographic imaging data sensitive to ventilation heterogeneity is synthesized withRLandELdata to help identify which airway constriction conditions could be consistent with both data sets. An ultimate goal would be personalized predictions. ©2003 Biomedical Engineering Society.PAC2003: 8719Uv, 8710+e, 8758Fg