HORMONAL REGULATION OF CELL DIVISION IN EPITHELIAL AND CONNECTIVE TISSUES OF MOUSE UTERUS
HORMONAL REGULATION OF CELL DIVISION IN EPITHELIAL AND CONNECTIVE TISSUES OF MOUSE UTERUS
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DOI：
10.1677/joe.0.0410363
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发表时间：
1968-01-01
影响因子：
4
通讯作者：
FINN, CA
中科院分区：
文献类型：
--
作者：
MARTIN, L;FINN, CA
Progesterone treatment significantly altered the response of the mouse uterus to estradiol -17[beta]. Estradiol given alone produced many mitoses in the luminal and glandular epithelia but not in the connective tissue stroma. After treatment with progesterone this pattern was reversed and estradiol produced many mitoses in the stroma but few in the epithelia. Production of stomal cell division was influenced by the dose of progesterone and by the period of treatment; a single day of treatment greatly reduced the numbers of epithelial mitoses produced by estradiol but did not greatly increase stromal mitosis. At least 3 days'' treatment was necessary for a maximal stromal response. Doses of estradiol sufficient to inhibit implantation and deciduomata production did not reverse the stromal response but did overcome, in part, the progestational suppression of epithelial mitosis, producing large numbers of mitoses in the luminal but not in the glandular epithelium.
