Antioxidant and antibacterial activity of two compounds (forsythiaside and forsythin) isolated from Forsythia suspensa
Antioxidant and antibacterial activity of two compounds (forsythiaside and forsythin) isolated from Forsythia suspensa
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DOI：
10.1211/jpp.60.2.0016
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发表时间：
2008-02-01
影响因子：
3.3
通讯作者：
Sun, Wenji
中科院分区：
文献类型：
--
作者：
Qu, Huanhuan;Zhang, Yongmin;Sun, Wenji
连翘Forsythia suspensa（Thunb.）法尔在亚洲的传统医药中已被广泛用于治疗淋病、丹毒、炎症、发热、溃疡等疾病。近年来，对该植物的抗氧化和抗菌活性的研究越来越多.然而，科学证明的信息有限。从该植物中分离得到两个化合物：红花苷和红花苷。因此，本研究的目的是测定两个主要的和独特的化合物分离的抗氧化活性和抗菌性能，并开发天然化合物的抗氧化剂和抗菌剂。采用1-二苯基-2-苦基肼（DPPH）清除法测定其抗氧化活性，采用微量滴定板法测定其体外抗菌活性。连翘酯苷具有较强的抗氧化和抗菌活性，而连翘苷的抗氧化和抗菌活性较弱。由于这些性质，该研究可以进一步扩展到开发作为天然来源的替代抗氧化剂和抗菌剂的红花苷的可能应用。
Forsythia suspensa (Thunb.) Vahl. has been widely used in traditional medicines in Asia to treat gonorrhoea, erysipelas, inflammation, pyrexia, ulcer and other diseases. Recently the investigation has been focused on the antioxidant and antibacterial activity of this plant. However, limited scientifically proven information is available. We isolated two compounds (forsythiaside and forsythin) from this plant. The aims of this investigation, therefore, were to assay antioxidant activity and antibacterial properties of the two main and distinctive compounds isolated and to exploit antioxidants and antibacterial agents from natural compounds. The antioxidant activity was estimated using the 1-diphenyl-2-picrylhydrazyl (DPPH) scavenging activity method and the in-vitro antimicrobial activity was evaluated by microtitre plate method. Forsythiaside was found to possess strong antioxidant and antibacterial activity but forsythin was much weaker. Owing to these properties, the study can be further extended to exploit the possible application of forsythiaside as an alternative antioxidant and antibacterial agent of natural origin.