Anti-HIV-1 limonoid: first isolation from Clausena excavata.
Anti-HIV-1 limonoid: first isolation from Clausena excavata.
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抗 HIV-1 柠檬苦素：首次从黄皮中分离得到。
DOI：
10.1002/ptr.1381
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发表时间：
2003
期刊：
影响因子：
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通讯作者：
Yoosook,Chalobon
中科院分区：
文献类型：
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作者：
Sunthitikawinsakul,Arunrat;Kongkathip,Ngampong;Kongkathip,Boonsong;Phonnakhu,Sida;Daly,JohnW;Spande,ThomasF;Nimit,Yuth;Napaswat,Chanita;Kasisit,Jittra;Yoosook,Chalobon
从山茅中分离到一种柠檬素，子茅内酯- 1 -乙醚(1)和两种香豆素，牙素(2)和非牙素(3)。从根状茎和根的粗乙醇提取物中获得了类柠檬素1，但以前从未从柠檬中分离过。并显示出HIV‐1抑制活性。香豆素2和香豆素3的结构与抗HIV - 1物质（+）‐calanolide A(4)有关。在合胞体抗HIV - 1活性试验中，这两种方法都对细胞产生毒性。这些化合物，1 - 3，对KB和BC‐1细胞系没有任何细胞毒性作用（ic50值bb0 20µg/mL）。版权所有©2003 John Wiley & Sons， Ltd
A limonoid, clausenolide‐1‐ethyl ether (1) and two coumarins, dentatin (2) andnor‐dentatin (3), were isolated fromClausena excavata. Limonoid 1 was obtained from the crude ethanol extract of the rhizomes and the roots but had not previously been isolated fromC. excavataand exhibited HIV‐1 inhibitory activity. Coumarins 2 and 3, with their structures related to an anti‐HIV‐1 substance, (+)‐calanolide A (4), were obtained from the crude chloroform extract of the rhizomes. Both induced toxicity to cells used in a syncytium assay for anti‐HIV‐1 activity. These compounds, 1–3, did not show any cytotoxic effect against KB and BC‐1 cell lines (IC50value > 20 µg/mL). Copyright © 2003 John Wiley & Sons, Ltd.