The Role of the Sweet Taste Receptor in Enteroendocrine Cells and Pancreatic β-Cells.
The Role of the Sweet Taste Receptor in Enteroendocrine Cells and Pancreatic β-Cells.
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DOI：
10.4093/dmj.2011.35.5.451
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发表时间：
2011-10
影响因子：
5.9
通讯作者：
Nakagawa Y
中科院分区：
文献类型：
--
作者：
Kojima I;Nakagawa Y
甜味感受器在舌头味蕾中的味觉细胞中表达。这种感受器感知口腔内的甜味物质，激活味觉细胞，并将味觉信号传递给邻近的神经元。甜味受体是两种G蛋白偶联受体T1R2和T1R3的异源二聚体。最近的研究表明，该受体也表达于胃外系统，包括胃肠道、胰腺β细胞和大脑中的葡萄糖反应神经元。在肠道中，甜味受体调节肠促胰岛素激素的分泌和从肠腔摄取葡萄糖。在β细胞中，甜味受体的激活导致胰岛素分泌的刺激。总的来说，甜味受体在人体能量的识别和代谢中起着重要的作用。
The sweet taste receptor is expressed in taste cells located in taste buds of the tongue. This receptor senses sweet substances in the oral cavity, activates taste cells, and transmits the taste signals to adjacent neurons. The sweet taste receptor is a heterodimer of two G protein-coupled receptors, T1R2 and T1R3. Recent studies have shown that this receptor is also expressed in the extragustatory system, including the gastrointestinal tract, pancreatic β-cells, and glucose-responsive neurons in the brain. In the intestine, the sweet taste receptor regulates secretion of incretin hormones and glucose uptake from the lumen. In β-cells, activation of the sweet taste receptor leads to stimulation of insulin secretion. Collectively, the sweet taste receptor plays an important role in recognition and metabolism of energy sources in the body.