The Drosophila lymph gland as a developmental model of hematopoiesis
The Drosophila lymph gland as a developmental model of hematopoiesis
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DOI：
10.1242/dev.01837
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发表时间：
2005-06-01
期刊：
影响因子：
4.6
通讯作者：
Banerjee, U
中科院分区：
文献类型：
--
作者：
Jung, SH;Evans, CJ;Banerjee, U
果蝇的造血发生在一个叫做淋巴腺的特殊器官中。在淋巴腺结构和基因表达的系统分析中，我们定义了血细胞（血细胞）从其前体成熟的发育步骤。特别地，描述了造血进展期间淋巴腺中血细胞成熟、信号传导和增殖的不同区域。血细胞发育的不同阶段已根据标记物表达进行分类，并置于发育龛内：静止原血细胞的髓区，成熟血细胞的皮质区和称为专门信号血细胞的后部信号中心的区域。这建立了一个框架，识别果蝇血细胞，在不同的成熟阶段，并提供了一个遗传基础的空间和时间的事件，管理血细胞的发展。本分析中鉴定的细胞事件进一步确立了果蝇作为造血的模型系统。
Drosophila hematopoiesis occurs in a specialized organ called the lymph gland. In this systematic analysis of lymph gland structure and gene expression, we define the developmental steps in the maturation of blood cells (hemocytes) from their precursors. In particular, distinct zones of hemocyte maturation, signaling and proliferation in the lymph gland during hematopoietic progression are described. Different stages of hemocyte development have been classified according to marker expression and placed within developmental niches: a medullary zone for quiescent prohemocytes, a cortical zone for maturing hemocytes and a zone called the posterior signaling center for specialized signaling hemocytes. This establishes a framework for the identification of Drosophila blood cells, at various stages of maturation, and provides a genetic basis for spatial and temporal events that govern hemocyte development. The cellular events identified in this analysis further establish Drosophila as a model system for hematopoiesis.