Effect of Ki-67 Expression Levels and Histological Grade on Breast Cancer Early Relapse in Patients with Different Immunohistochemical-based Subtypes
Effect of Ki-67 Expression Levels and Histological Grade on Breast Cancer Early Relapse in Patients with Different Immunohistochemical-based Subtypes
复制标题
Ki-67 表达水平和组织学分级对不同免疫组织化学亚型患者乳腺癌早期复发的影响。
DOI：
10.1038/s41598-020-64523-1
复制
发表时间：
2020-05-06
影响因子：
4.6
通讯作者：
Yu, Ke-Da
中科院分区：
文献类型：
--
作者：
Liang, Qin;Ma, Ding;Yu, Ke-Da
这项回顾性分析评估了Ki-67和组织学分级之间的相互作用及其在不同乳腺癌亚型中的预后作用。总共有2，573名乳腺癌患者接受了手术，并由乳腺病理学家评估了他们的组织学分级和Ki-67值。Ki-67指数中位数为15%，用作Ki-67低/高表达的临界值。计算和比较无复发生存期（RFS），结果表明Ki-67表达与所有乳腺癌患者的组织学分级显著相关（p
This retrospective analysis evaluated the interaction between Ki-67 and histological grade and their prognostic role in different breast cancer subtypes. In total, 2,573 breast cancer patients underwent surgery, and their histological grade and Ki-67 values were evaluated by breast pathologists. The median Ki-67 index was 15%, which was used as the cut-off for low/high Ki-67 expression. Recurrence-free survival (RFS) was calculated and compared, and the results indicated that Ki-67 expression was significantly associated with histological grade in all breast cancer patients (p