Statin use and lipid levels in older adults: National Health and Nutrition Examination Survey, 2001 to 2006.
Statin use and lipid levels in older adults: National Health and Nutrition Examination Survey, 2001 to 2006.
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DOI：
10.1016/j.jacl.2010.10.002
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发表时间：
2010-11
影响因子：
4.4
通讯作者：
Booth, Benjamin
中科院分区：
文献类型：
--
作者：
Robinson, Jennifer G.;Booth, Benjamin
Statins are the evidence-based drugs of choice for the prevention of cardiovascular disease (CVD). Statin utilization has increased in those ≥65 years, but patterns of utilization in subgroups of elderly are unknown. Weighted data from the 2001 through 2006 National Health and Nutrition Examination Surveys were combined for this analysis. Statin use increased in all sex, age, and risk categories between the 2001-2002 and 2005-2006 surveys, when the highest use was by men aged 65-74 years with CVD (80%), followed by women with CVD aged 65-79 (64-69%), women and men with diabetes aged 65-69 (56 and 94%, respectively); statins were used by <42% of individuals without CVD or diabetes. In adjusted logistic regression models, those with diabetes [odds ratio (OR) 2.1, 95% CI 1.8-2.6], CVD but no diabetes (OR 3.0, 95% CI 2.5-3.6), and CVD and diabetes (OR 5.2, 95% CI 3.9-7.1) were more likely to use statins than those without CVD or diabetes, p=<0.001. A significant interaction between age and gender was found, where 75-79 year old women were more likely to report statin use than men aged 65-69 (OR = 2.07, 95% CI = 1.29, 3.35). In general, those aged 65-69 were more likely to use a statin than those ≥70 (OR 0.57, 95% CI 0.39-1.08, p=0.08). Non-white persons aged ≥70 reported less statin use than whites aged 65-69 (OR=0.17, 95% CI 0.10-0.30). Mexican Americans were less likely to report statin use than whites. Although statin use has increased substantially over time, statins remain underutilized in both the primary and secondary prevention of CVD in the elderly, with some evidence of disparities by sex, advancing age, and race/ethnicity.
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