Cubism and the cell cycle: the many faces of the APC/C
Cubism and the cell cycle: the many faces of the APC/C
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DOI：
10.1038/nrm3155
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发表时间：
2011-08
影响因子：
112.7
通讯作者：
J. Pines
中科院分区：
文献类型：
--
作者：
J. Pines
人们并不经常从分析立体主义中寻找对细胞周期控制的见解，但巴勃罗·毕加索（Pablo Picasso）在他说“每一个创造的行为首先是一个破坏的行为”时，优美地概括了基本原理。在细胞周期的正确时刻快速破坏特定的细胞周期调节因子，确保子细胞从其母亲那里获得相等和相同的染色体组，并且DNA复制总是跟随有丝分裂。值得注意的是，有一种蛋白质复合物负责这种手术精度，APC/C（后期促进复合物，也称为环体）。APC/C受其共激活因子和纺锤体组装检查点的严格调控。
One does not often look to analytic cubism for insights into the control of the cell cycle, but Pablo Picasso beautifully encapsulated the fundamentals when he said that “every act of creation is, first of all, an act of destruction”. The rapid destruction of specific cell cycle regulators at just the right moment in the cell cycle ensures that daughter cells receive an equal and identical set of chromosomes from their mother and that DNA replication always follows mitosis. Remarkably, one protein complex is responsible for this surgical precision, the APC/C (anaphase-promoting complex, also known as the cyclosome). The APC/C is tightly regulated by its co-activators and by the spindle assembly checkpoint.