Frequent Δ9- tetrahydrocannabinol exposure during adolescence impairs sociability in adult mice exposed to an aversive painful stimulus.
Frequent Δ9- tetrahydrocannabinol exposure during adolescence impairs sociability in adult mice exposed to an aversive painful stimulus.
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青春期频繁接触α9-四氢大麻酚会损害暴露于厌恶性疼痛刺激的成年小鼠的社交能力。
DOI：
10.1016/j.euroneuro.2021.07.007
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Piomelli,Daniele
中科院分区：
文献类型：
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作者：
MabouTagne,Alex;Fotio,Yannick;AlanSprings,Zachary;Su,Shiqi;Piomelli,Daniele
早期接触Δ9-四氢大麻酚(Δ9-THC)，大麻的令人陶醉的成分，可能会在参与调节社会性的大脑结构中产生持久的神经化学变化，但目前尚不清楚这些变化如何影响晚年的社会行为。在本研究中，我们在青春期(出生后30至43天)将雄性小鼠暴露于中等剂量的Δ9-THC(5 mg/kg，腹膜内)，当动物达到成年期(PND70)时，我们评估了它们在注射化学刺激性福尔马林(1%VOL，足底内)之前和3周后在三室社交任务中的表现，这会在小鼠中产生即时和持续的疼痛相关行为。之前的Δ-9-THC治疗没有改变对照组成年小鼠的社会互动，但扰乱了在福尔马林注射后出现持久感觉异常的动物的社交互动。研究结果表明，青春期频繁接触Δ-9-thc会导致雄性小鼠社交行为的潜伏期功能障碍，成年后当动物处于厌恶状态时，这种功能就会暴露出来。
Early-life exposure to Δ9-tetrahydrocannabinol (Δ9-THC), the intoxicating constituent of cannabis, may produce enduring neurochemical changes in brain structures involved in the regulation of sociality but it is still unclear how such changes influence social behavior later in life. In the present study, we exposed male mice to moderate daily doses of Δ9-THC (5 mg/kg, intraperitoneal) during adolescence (postnatal day, PND, 30 to 43) and, when animals reached adulthood (PND70), we assessed their performance in the three-chamber social interaction task before and 3 weeks after injection of the chemical irritant formalin (1 % vol, intraplantar), which produces both immediate and persistent pain-related behaviors in mice. Prior Δ9-THC treatment did not alter social interaction in control adult mice but disrupted it in animals that developed lasting sensory abnormalities following formalin injection. The findings suggest that frequent exposure to Δ9-THC during adolescence causes in male mice a dormant dysfunction in social behavior which can be unmasked in adulthood when the animals experience an aversive state.