Depressive symptoms in patients with chronic hepatitis C are correlated with elevated plasma levels of interleukin-1β and tumor necrosis factor-α
Depressive symptoms in patients with chronic hepatitis C are correlated with elevated plasma levels of interleukin-1β and tumor necrosis factor-α
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DOI：
10.1016/j.neulet.2007.11.001
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发表时间：
2008-01-17
影响因子：
2.5
通讯作者：
Hauser, Peter
中科院分区：
文献类型：
--
作者：
Loftis, Jennifer M.;Huckans, Marilyn;Hauser, Peter
研究表明，细胞因子在抑郁症的生物学中发挥作用。在这项研究中，我们评估了慢性丙型肝炎（HCV）患者和非HCV患者的抑郁和细胞因子水平，以更好地评估慢性感染如何改变细胞因子水平，并可能导致抑郁症。通过波特兰VA医疗中心招募了23名HCV感染者（n=16）和非HCV感染者（n=7）。研究参与者被排除在目前的药物滥用，精神障碍，肝硬化，或干扰素（IFN）治疗。参与者完成贝克抑郁量表-II（BDI-II）和抽血以评估血浆细胞因子水平[即，白细胞介素（IL）-1 β、IL-10和肿瘤坏死因子（TNF）-α]。进行t检验以比较有或没有HCV的患者中的细胞因子水平。与无HCV的患者相比，HCV患者显示出更高的TNF-α值（组平均值分别为7.94和3.41 pg/mL，p=0.047）。对于评估的其他细胞因子，组间无显著差异。在HCV患者中，TNF-α和IL-1 β水平（而非IL-10）与BDI-II评分相关[分别为r=0.594，p=0.020和r=0.489，p=0.055（趋势）]。总之，这些结果显示了HCV患者抑郁症状的严重程度与促炎细胞因子的表达之间的关联。未来的研究应探讨炎症介质如何在慢性感染患者的特定抑郁症状的表达中发挥作用。HCV患者是研究这种关系的一个有趣的模型。出版社：Elsevier爱尔兰Ltd.
Studies suggest that cytokines have a role in the biology of depression. In this study, we evaluated depression and cytokine levels in patients with and without chronic hepatitis C (HCV) to better assess how chronic infection alters cytokines levels and may contribute to depressive symptomotology. Twenty-three adults with (n=16) and without (n=7) HCV were recruited through the Portland VA Medical Center. Research participants were excluded for current substance abuse, psychotic disorder, liver cirrhosis, or interferon (IFN) therapy. Participants completed the Beck Depression Inventory-II (BDI-II) and a blood draw to evaluate plasma cytokine levels [i.e., interleukin (IL)-1 beta, IL-10 and tumor necrosis factor (TNF)-alpha]. t-Tests were performed to compare cytokine levels in patients with or without HCV. HCV patients showed higher TNF-alpha values compared to patients without HCV (group means =7.94 vs. 3.41 pg/mL, respectively, p=0.047). There were no significant differences between the groups for the other cytokines assessed. In patients with HCV, TNF-alpha and IL-1 beta levels (but not IL-10) were correlated with BDI-II scores [r=0.594, p=0.020 and r=0.489, p=0.055 (trend), respectively]. Taken together, these results show an association between severity of depressive symptoms and expression of pro-inflammatory cytokines in patients with HCV. Future studies should investigate how inflammatory mediators play a role in the expression of specific depressive symptoms in patients with chronic infection. Patients with HCV represent an interesting model to examine this relationship. Published by Elsevier Ireland Ltd.