Serum Neurofilament Light Chain Levels in the Intensive Care Unit: Comparison between Severely Ill Patients with and without Coronavirus Disease 2019
Serum Neurofilament Light Chain Levels in the Intensive Care Unit: Comparison between Severely Ill Patients with and without Coronavirus Disease 2019
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DOI：
10.1002/ana.26004
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发表时间：
2021-01-11
影响因子：
11.2
通讯作者：
Kuhle, Jens
中科院分区：
文献类型：
--
作者：
Sutter, Raoul;Hert, Lisa;Kuhle, Jens
有新的证据表明2019年冠状病毒病(新冠肺炎)的多种神经系统表现，但关于它们是否反映了神经系统的结构性损害，人们知之甚少。血清神经丝轻链(SNFL)是神经元损伤的特异性生物标志物。我们测量了29名新冠肺炎危重患者、10名非新冠肺炎危重患者和259名健康对照的SNFL浓度。在调整了神经系统合并症和年龄后，新冠肺炎患者的SNFL浓度高于两个对照组。较高的SNFL水平与不良的短期结果相关，这表明神经元损伤在危重患者中很常见和明显。
There is emerging evidence for multifarious neurological manifestations of coronavirus disease 2019 (COVID-19), but little is known regarding whether they reflect structural damage to the nervous system. Serum neurofilament light chain (sNfL) is a specific biomarker of neuronal injury. We measured sNfL concentrations of 29 critically ill COVID-19 patients, 10 critically ill non-COVID-19 patients, and 259 healthy controls. After adjusting for neurological comorbidities and age, sNfL concentrations were higher in patients with COVID-19 versus both comparator groups. Higher sNfL levels were associated with unfavorable short-term outcome, indicating that neuronal injury is common and pronounced in critically ill patients.