The Mouse Genome Database (MGD): the model organism database for the laboratory mouse
The Mouse Genome Database (MGD): the model organism database for the laboratory mouse
复制标题
DOI：
10.1093/nar/30.1.113
复制
发表时间：
2002-01-01
影响因子：
14.9
通讯作者：
Eppig, JT
中科院分区：
文献类型：
--
作者：
Blake, JA;Richardson, JE;Eppig, JT
小鼠基因组数据库（MGD）是实验室小鼠的社区数据库资源，小鼠是解读人类基因组以及理解人类生物学和疾病的关键模式生物（http://www.informatics.jax.org）。MGD致力于提供一个精心整理、高度整合的信息资源，它不仅包含当前有关小鼠知识的共识观点，还特别提供人类和大鼠基因组的比较基因组信息。MGD包含大量有关小鼠基因的信息，用实验数据、证据陈述和引用支持所有基因属性的论断。有关等位基因和小鼠突变体的详细信息包括基因型、分子变异和表型描述。与美国国家生物技术信息中心（NCBI）、日本理化研究所（RIKEN）和瑞士生物信息学研究所蛋白质分析专家系统（SWISS - PROT）等其他数据提供者的广泛合作，实现了基因 - 序列关联的标准化以及基于共享序列整理的大型信息系统之间的稳固互联。近期对小鼠全长cDNA和辐射杂交定位的表达序列标签（EST）大型数据集的整合、广泛结构化词汇的持续开发和使用以及表型呈现的扩展，是本年度的发展亮点。
The Mouse Genome Database (MGD) is the community database resource for the laboratory mouse, a key model organism for interpreting the human genome and for understanding human biology and disease (http://www.informatics.jax.org). MGD strives to provide a highly curated, highly integrated information resource that not only includes the consensus view of current knowledge about the mouse, but also provides comparative genomic information particularly for human and rat genomes. MGD includes extensive information about mouse genes, supporting all gene attribute assertions with experimental data, statements of evidence and citation. Detailed information about alleles and mouse mutants includes genotype, molecular variant and phenotype descriptions. Extensive collaboration with other data providers such as NCBI, RIKEN and SWISS-PROT provides standardization of gene:sequence associations and robust interconnections between large information systems based on shared sequence curation. Recent integration of large datasets of mouse full-length cDNAs and radiation-hybrid mapped ESTs, the continued development and use of extensive structured vocabularies and the expansion of the representation of phenotypes highlight this year's developments.