Total Sleep Time and Other Sleep Characteristics Measured by Actigraphy Do Not Predict Incident Hypertension in a Cohort of Community-Dwelling Older Men
Total Sleep Time and Other Sleep Characteristics Measured by Actigraphy Do Not Predict Incident Hypertension in a Cohort of Community-Dwelling Older Men
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DOI：
10.5664/jcsm.2756
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发表时间：
2013-01-01
影响因子：
4.3
通讯作者：
Barrett-Connor, Elizabeth
中科院分区：
文献类型：
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作者：
Fung, Maple M.;Peters, Katherine;Barrett-Connor, Elizabeth
研究目的：评估腕动描记法测量的总睡眠时间和其他睡眠特征是否能预测老年男性高血压的发生。研究对象是男性骨质疏松性骨折研究（MrOS）的辅助睡眠研究中的社区居民参与者，在活动记录时血压正常（基于自我报告，未使用抗高血压药物，收缩压< 140 mm Hg，舒张压< 90 mm Hg）。在853名67岁及以上（平均75.1岁）的社区居住男性中，使用经过验证的腕动记录仪获得睡眠测量（总睡眠时间[TST]），睡眠百分比[%-睡眠]，潜伏期和入睡后觉醒[WASO]），数据收集平均持续时间为5.2个连续24小时。我们在平均3.4年后的随访中评估了高血压事件（基于自我报告、使用降压药物或测量的收缩压≥ 140 mm Hg或舒张压≥ 90 mm Hg）。基线高血压前期定义为收缩压120至< 140 mm Hg或舒张压80至< 90 mm Hg。结果：随访时，31%的初始血压正常的男性（853例中有264例）患有高血压。与血压正常的男性相比，高血压患者的基线体重指数（BMI; kg/m2）更高，在睡眠访视时更有可能出现高血压前期。然而，TST（参考6至< 8 h; < 6 h OR 0.96 [95% CI 0.7，1.3]和>= 8 h OR 0.93 [0.5，1.7]），也没有其他活动记录仪测量的睡眠变量，包括% -睡眠（参考> 85%; < 70% OR 1.17 [0.66，2.08]）和70%至= 30 min OR 1.29 [0.94，1.76]），或WASO（参考< 30分钟; 30至< 60分钟OR 0.7 [0.43，1.14]和>= 60分钟OR 0.92 [0.58，1.47]）在发生高血压的社区居民男性与血压正常的社区居民男性之间存在差异。TST和其他睡眠参数确定的手腕活动与社区居住的老年男性的高血压事件无关。
Study Objective: To evaluate whether actigraphy-measured total sleep time and other sleep characteristics predict incident hypertension in older men.Methods: Study subjects were community-dwelling participants in the ancillary sleep study of the Osteoporotic Fractures in Men Study (MrOS) who were normotensive at the time of actigraphy (based on self-report, lack of antihypertensive medication use, and with systolic blood pressure < 140 mm Hg and diastolic blood pressure < 90 mm Hg). In 853 community-dwelling men 67 years and older (mean 75.1 years), sleep measures (total sleep time [TST]), percent sleep [%-sleep], latency, and wake after sleep onset [WASO]) were obtained using validated wrist actigraphy with data collected over a mean duration of 5.2 consecutive 24-h periods. We evaluated incident hypertension (based on self-report, use of antihypertensive medication, or measured systolic blood pressure >= 140 mm Hg or diastolic blood pressure >= 90 mm Hg) at a follow-up visit an average of 3.4 years later. Baseline prehypertension was defined as a systolic blood pressure 120 to < 140 mm Hg or diastolic blood pressure 80 to < 90 mm Hg.Results: At follow-up, 31% of initially normotensive men were hypertensive (264 of 853). Those with incident hypertension had higher baseline body mass index (BMI; kg/m(2)) and were more likely to have had prehypertension at the sleep visit than those men who remained normotensive. However, neither TST (reference 6 to < 8 h; < 6 h OR 0.96 [95% CI 0.7, 1.3] and >= 8 h OR 0.93 [0.5, 1.7]) nor the other actigraphic-measured sleep variables, including % -sleep (reference > 85%; < 70% OR 1.17 [0.66, 2.08]) and 70% to = 30 min OR 1.29 [0.94, 1.76]), or WASO (reference < 30 min; 30 to < 60 min OR 0.7 [0.43, 1.14] and >= 60 min OR 0.92 [0.58, 1.47]) differed in those community-dwelling men who developed incident hypertension compared to those who remained normotensive.Conclusion: TST and other sleep parameters determined by wrist actigraphy were not associated with incident hypertension in community-dwelling older men.