Modifying the Organ Matrix Pre-engraftment: A New Transplant Paradigm?
Modifying the Organ Matrix Pre-engraftment: A New Transplant Paradigm?
复制标题
修改移植前的器官基质：新的移植范式？
DOI：
10.1016/j.molmed.2019.04.002
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发表时间：
2019-07
影响因子：
13.6
通讯作者：
ra R
中科院分区：
文献类型：
--
作者：
Yaron Jordan R;Kwiecien Jacek M;Zhang Liqiang;Ambadapadi Sriram;Wakefield Dara N;Clapp William L;Dabrowski Wojciech;Burgin Michelle;Munk Barbara H;McFadden Grant;Chen Hao;Lucas Alex;ra R
用于移植的实体器官的可用性仍然很低，并且对保存移植组织的活力的方法存在实质性需求。实体器官移植排斥反应的抑制传统上集中在阻断宿主免疫淋巴细胞应答的高效T细胞抑制剂上。然而，持续的和破坏性的先天性和获得性免疫反应仍然难以治疗，导致晚期移植物丢失。预处理移植物以减少器官排斥反应提供了一种替代策略。正在研究使用抗血栓药、干细胞、遗传修饰、调节供体器官的基础结构成分（结缔组织、CT;糖萼）和新器官工程的方法。我们在这里讨论新的方法来修改移植器官移植前，作为一种方法，以减少排斥反应，重点放在CT矩阵。
The availability of solid organs for transplantation remains low and there is a substantial need for methods to preserve the viability of grafted tissues. Suppression of solid-organ transplant rejection has traditionally focused on highly effective T cell inhibitors that block host immune lymphocyte responses. However, persistent and destructive innate and acquired immune reactions remain difficult to treat, causing late graft loss. Pretreatment of grafts to reduce organ rejection provides an alternate strategy. Approaches using antithrombotics, stem cells, genetic modifications, modulation of infrastructural components (connective tissue, CT; glycocalyx) of donor organs, and engineering of new organs are under investigation. We discuss here new approaches to modify transplanted organs prior to engraftment as a method to reduce rejection, focusing on the CT matrix.
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影响因子：
3.9
作者：
Liang F;Wamala I;Scalea J;Tena A;Cormack T;Pratts S;Duran-Struuck R;Elias N;Hertl M;Huang CA;Sachs DH
通讯作者：
Sachs DH
影响因子：
120.7
作者：
Traverse, Jay H.;Henry, Timothy D.;Pepine, Carl J.;Willerson, James T.;Zhao, David X. M.;Ellis, Stephen G.;Forder, John R.;Anderson, R. David;Hatzopoulos, Antonis K.;Penn, Marc S.;Perin, Emerson C.;Chambers, Jeffrey;Baran, Kenneth W.;Raveendran, Ganesh;Lambert, Charles;Lerman, Amir;Simon, Daniel I.;Vaughan, Douglas E.;Lai, Dejian;Gee, Adrian P.;Taylor, Doris A.;Cogle, Christopher R.;Thomas, James D.;Olson, Rachel E.;Bowman, Sherry;Francescon, Judy;Geither, Carrie;Handberg, Eileen;Kappenman, Casey;Westbrook, Lynette;Piller, Linda B.;Simpson, Lara M.;Baraniuk, Sarah;Loghin, Catalin;Aguilar, David;Richman, Sara;Zierold, Claudia;Spoon, Daniel B.;Bettencourt, Judy;Sayre, Shelly L.;Vojvodic, Rachel W.;Skarlatos, Sonia I.;Gordon, David J.;Ebert, Ray F.;Kwak, Minjung;Moye, Lemuel A.;Simari, Robert D.
通讯作者：
Simari, Robert D.
DOI：
10.1001/jama.2013.282674
发表时间：
2014-01-15
期刊：
JAMA
影响因子：
--
作者：
Traverse JH;Henry TD;Pepine CJ;Willerson JT;Ellis SG
通讯作者：
Ellis SG
影响因子：
3.5
作者：
Rocca DG;Willenberg BJ;Qi Y;Simmons CS;Rubiano A;Ferreira LF;Huo T;Petersen JW;Ruchaya PJ;Wate PS;Wise EA;Handberg EM;Cogle CR;Batich CD;Byrne BJ;Pepine CJ
通讯作者：
Pepine CJ
影响因子：
4.1
作者：
McGregor CGA;Byrne GW
通讯作者：
Byrne GW