Recurrence of empty follicle syndrome with stimulated IVF cycles
Recurrence of empty follicle syndrome with stimulated IVF cycles
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DOI：
10.3109/09513590.2011.631629
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发表时间：
2012-04-01
影响因子：
2
通讯作者：
Hourvitz, A.
中科院分区：
文献类型：
--
作者：
Baum, M.;Machtinger, R.;Hourvitz, A.
目的：了解复发性空卵泡综合征（EFS）的发病情况，并分析其相关因素。方法：回顾性分析1998年至2006年在我院体外受精（IVF）单位提取卵母细胞的周期与所有EFS周期的比较。结果：8292个试管婴儿周期中，163个（2.0%）出现空卵泡。EFS的风险因素包括高龄(37.7 + / - 6.0年和34.2 + / - 6.0年,p < 0.001),不再不孕(8.8 + / - 10.6年和6.3 + / - 8.4年,p < 0.05),高基线促卵泡激素水平(8.7 + / - 4.7 IU / L和6.7 + / - 2.9 IU / L, p < 0.001)和人体绒毛膜促性腺激素注射前E2水平较低(499.9 + / - 480.9 pg / mL和1516.3 + / - 887.5 pg / mL, p < 0.001)与案件中,卵子被检索。在EFS患者中，15.8%的后续周期发生复发性EFS。结论：EFS在大多数患者中为散发性事件。然而，大约16%的患者可能会复发。这些病例可能是不良反应的一种变体形式，反复EFS综合征的患者应被告知他们的怀孕机会。
Aim: To determine the incidence of recurrent empty follicle syndrome (EFS) and to analyse the factors associated with this phenomenon. Methods: Retrospective analysis comparing all EFS cycles with cycles in which oocytes were retrieved in our in vitro fertilization (IVF) unit between 1998 and 2006. Results: Of 8292 IVF cycles, 163 (2.0%) resulted in empty follicles. Risk factors for EFS included advanced age (37.7 +/- 6.0 years vs. 34.2 +/- 6.0 years, p < 0.001), longer infertility (8.8 +/- 10.6 years vs. 6.3 +/- 8.4 years, p < 0.05), higher baseline follicle-stimulating hormone levels (8.7 +/- 4.7 IU/L vs. 6.7 +/- 2.9 IU/L, p < 0.001) and lower E2 levels before the human chorionic gonadotropin injection (499.9 +/- 480.9 pg/mL vs. 1516.3 +/- 887.5 pg/mL, p < 0.001) compared with cases in which ova were retrieved. Among patients with EFS, recurrent EFSs occurred in 15.8% of subsequent cycles. Conclusion: The EFS is a sporadic event in the majority of patients. However, in about 16% of the patients, EFS may recur. These cases may be a variant form of poor response and patients with repetitive EFS syndrome should be counseled concerning their chances to conceive.