Left Frontal Hub Connectivity during Memory Performance Supports Reserve in Aging and Mild Cognitive Impairment.
Left Frontal Hub Connectivity during Memory Performance Supports Reserve in Aging and Mild Cognitive Impairment.
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DOI：
10.3233/jad-170360
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发表时间：
2017
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影响因子：
--
通讯作者：
Ewers M
中科院分区：
文献类型：
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作者：
Franzmeier N;Hartmann JC;Taylor ANW;Araque Caballero MÁ;Simon-Vermot L;Buerger K;Kambeitz-Ilankovic LM;Ertl-Wagner B;Mueller C;Catak C;Janowitz D;Stahl R;Dichgans M;Duering M;Ewers M
衰老和阿尔茨海默病(AD)的储备被定义为在存在神经退化的情况下保持相对较高的认知水平，这种能力通常与高等教育和其他生活因素有关。最近的证据表明，额顶控制网络内较高的静息状态功能连接，特别是左额皮质(LFC)中枢，有助于更高的储备。根据这些先前的静息状态fMRI结果，我们探讨了作为储备神经底物的LFC中枢与记忆任务相关的功能连接。在老年对照组(CN，n = 37)和轻度认知障碍患者(n = ，n MCI，n LFC 17)中，我们使用广义心理生理相互作用分析，在成功的面孔-名字联想学习期间评估了LFC中枢的全球连通性。储备被量化为残存记忆表现，考虑了性别和神经退行性变的代用品(年龄、海马萎缩和APOE基因)。我们发现，在成功记忆过程中，更高的教育程度与CN和MCI中更高的LFC连接性有关。此外，较高的LFC连通性预示着较高的剩余内存(即，保留)。这些结果表明，在健康和病理性衰老中，较高的LFC连接性有助于储备。
Reserve in aging and Alzheimer’s disease (AD) is defined as maintaining cognition at a relatively high level in the presence of neurodegeneration, an ability often associated with higher education among other life factors. Recent evidence suggests that higher resting-state functional connectivity within the frontoparietal control network, specifically the left frontal cortex (LFC) hub, contributes to higher reserve. Following up these previous resting-state fMRI findings, we probed memory-task related functional connectivity of the LFC hub as a neural substrate of reserve. In elderly controls (CN, n = 37) and patients with mild cognitive impairment (MCI, n = 17), we assessed global connectivity of the LFC hub during successful face-name association learning, using generalized psychophysiological interaction analyses. Reserve was quantified as residualized memory performance, accounted for gender and proxies of neurodegeneration (age, hippocampus atrophy, and APOE genotype). We found that greater education was associated with higher LFC-connectivity in both CN and MCI during successful memory. Furthermore, higher LFC-connectivity predicted higher residualized memory (i.e., reserve). These results suggest that higher LFC-connectivity contributes to reserve in both healthy and pathological aging.