MicroRNAs: small molecule, big potential for coronary artery disease.
MicroRNAs: small molecule, big potential for coronary artery disease.
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DOI：
10.1093/eurheartj/ehw067
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发表时间：
2016-03
影响因子：
39.3
通讯作者：
R. Widmer;L. Lerman;A. Lerman
中科院分区：
文献类型：
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作者：
R. Widmer;L. Lerman;A. Lerman
这篇社论引用了D.M. Leistner等人的“血管mirna的冠状动脉梯度和冠状动脉粥样硬化斑块特征”。MicroRNAs （miRs）是最近才发现的一种微小的表观遗传沉默现象，它正诱人地接近于成为冠状动脉疾病（CAD）的可实现诊断和治疗焦点，本期杂志上发表的研究结果可能提供了支持性数据，使我们能够开始认真地致力于实现这一目标。这些小的非编码核苷酸序列通过与竞争序列结合来抑制蛋白质翻译，已被证明有助于从肾脏和神经疾病到肥胖和酗酒的病理1,2在他们的手稿中，Leistner等人。对冠状动脉病变与mir之间的潜在联系做出了值得注意的贡献值得注意的是，作者描述了总体斑块负荷之间的关联，以及相对于miR-126-3p、miR-145-5p、miR-155-5p和miR-29b-3p，从冠状动脉循环的动脉到静脉方面的梯度。此外，作者还证明了miR-126-3p、miR-126-5p、miR-145-5p、miR-15-5p和miR-29-b-3p这些经冠状动脉梯度检测潜在易损斑块的预测能力，这些易损斑块由薄帽纤维粥样瘤（TCFAs）通过整合光学相干断层扫描（OCT）显示，这是一种新型冠状动脉内成像方式。尽管这些数据本质上是横断面的，并且应该注意通常的miR方法问题，但这些作者已经为易损斑块的病理生理学和miR之间的潜在联系提供了假设生成数据。重要的是，作者采用了一种生理方法，在适当接受冠状动脉造影的患者中收集经冠状动脉梯度的磁共振成像，并结合OCT提供的解剖学优势来成像动脉粥样硬化斑块。得到的数据是……
This editorial refers to ‘Transcoronary gradients of vascular miRNAs and coronary atherosclerotic plaque characteristics’, by D.M. Leistner et al . on doi:10.1093/eurheartj/ehw047 MicroRNAs (miRs), the diminutive epigenetic silencing phenomena only recently discovered, are moving tantalizing close to becoming a realizable diagnostic and therapeutic focus for coronary artery disease (CAD), and the results presented in this issue of the journal just may have provided supportive data allowing that work to begin in earnest intent on achieving that goal. These small non-coding nucleotide sequences that repress protein translation by binding to competing sequences have been shown to be contributory to pathologies from renal and neural diseases to obesity and alcoholism.1,2 In their manuscript, Leistner et al . present a noteworthy contribution to a potential link between tenuous coronary pathology and miRs.3 Notably, the authors describe associations between the overall plaque burden in addition to gradients from the arterial to venous aspects of the coronary circulation with respect to miR-126-3p, miR-145-5p, miR-155-5p, and miR-29b-3p. Furthermore, the authors also demonstrate the predictive power of these transcoronary gradients of miR-126-3p, miR-126-5p, miR-145-5p, miR-15-5p, and miR-29-b-3p in detecting potentially vulnerable plaques as indicated by thin-cap fibroatheromas (TCFAs) by integrating optical coherence tomograpy (OCT), a novel intracoronary imaging modality. Although the data are cross-sectional in nature, and the usual miR methodological concerns should be heeded, these authors have provided hypothesis-generating data for a potential link between the pathophysiology of vulnerable plaques and miRs. Importantly, the authors use a physiological approach by gathering transcoronary gradients of the miRs in patients appropriately undergoing coronary angiography coupled with the anatomic advantages offered by OCT to image atherosclerotic plaques. The resultant data are …