Comparison of standard and optimized voxel-based morphometry for analysis of brain changes associated with temporal lobe epilepsy
Comparison of standard and optimized voxel-based morphometry for analysis of brain changes associated with temporal lobe epilepsy
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DOI：
10.1016/j.neuroimage.2004.07.030
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发表时间：
2004-11-01
期刊：
影响因子：
5.7
通讯作者：
Roberts, N
中科院分区：
文献类型：
--
作者：
Keller, SS;Wilke, M;Roberts, N
我们使用标准和优化的基于体素的形态计量学(VBM)，比较了人工体积分析确定的患有单侧海马萎缩(HA)的颞叶癫痫(TLE)患者与健康对照人群组内局部灰质差异的统计参数图(SPM)。我们还调查了定制神经解剖模板对SPM的影响。灰质浓度(GMC)和灰质体积(GMV)的标准和优化VBM分析正确识别HA，而不考虑用于归一化的模板。海马区和海马区异常的分布因技术不同而不同(标准v优化；GMC v GMV)，但不依赖于每种技术中的模板类型(默认v定制)。特别是，海马区GMC减少仅限于海马亚区，而海马头、体和尾部GMV减少。与标准和优化的GMC减影不同，左侧和右侧HA患者的双侧丘脑、豆状核、小脑和同侧内嗅皮质、咽周皮质和梭形回均可观察到对称性的GMV减影。这些结果表明，GMC(即灰质的区域分布)和GMV(即体积本身)减少的分组SPM可以识别已被手动感兴趣区技术量化的局灶性萎缩，尽管在GMC分析中影响减弱。与GMC的SPM不同，GMV的分析显示了类似于先前对顽固性TLE的感兴趣区体积和组织病理学研究的海马区外异常。我们认为，在神经系统疾病的研究中，优化的GMV VBM分析可能揭示GMC分析中未发现的细微神经解剖学变化。(C)2004 Elsevier Inc.保留所有权利。
We compared statistical parametric maps (SPMs) of group-wise regional gray matter differences between temporal lobe epilepsy (TLE) patients with unilateral hippocampal atrophy (HA) determined by manual volumetric analysis relative to a healthy control population using standard and optimized voxel-based morphometry (VBM). We also investigated the impact of customized neuroanatomical templates on SPMs. Standard and optimized VBM analyses of gray matter concentration (GMC) and gray matter volume (GMV) correctly identified HA, regardless of the template used for normalization. The distribution of hippocampal and extrahippocampal abnormalities differed according to the technique (standard v optimized; GMC v GMV), but was not dependent on template type (default v customized) within each technique. In particular, hippocampal GMC reduction was confined to subregions of hippocampus, whereas GMV reduction was observed in the hippocampal head, body, and tail. Unlike standard and optimized GMC reduction, symmetrical GMV reduction was observed in bilateral thalamus, lenticular nuclei, cerebellum, and ipsilateral entorhinal cortex, perirhinal cortex, and fusiform gyros in both left and right HA patients. These results show that group-wise SPMs of GMC (i.e., regional distribution of gray matter) and GMV (i.e., volume per se) reduction can identify focal atrophy that has been quantified with manual region of interest techniques, although effects are attenuated in analyses of GMC. Unlike SPMs of GMC, analyses of GMV revealed similar extrahippocampal abnormalities as previous region-of-interest volumetric and histopathological studies of intractable TLE. We suggest that in studies of neurological disorders, optimized VBM analyses of GMV may reveal subtle neuroanatomical changes that are not identified in analyses of GMC. (C) 2004 Elsevier Inc. All rights reserved.