Ionizing radiation-induced acoustics for radiotherapy and diagnostic radiology applications
Ionizing radiation-induced acoustics for radiotherapy and diagnostic radiology applications
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DOI：
10.1002/mp.12929
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发表时间：
2018-07-01
期刊：
影响因子：
3.8
通讯作者：
El Naqa, Issam
中科院分区：
文献类型：
--
作者：
Hickling, Susannah;Xiang, Liangzhong;El Naqa, Issam
声波是通过暴露于电离辐射脉冲束的物体中的热声效应而感生的。这一现象在放射治疗剂量测定和治疗指导以及低剂量放射成像方面具有有趣的潜在应用。经过20世纪80年代和90年代初在该领域的初步工作后，直到2013年，在超声传感器技术进步和放射治疗输送系统日益复杂的推动下，人们的兴趣重新焕发活力，几乎没有进行过研究。从那时起，已经进行了许多研究，并将电离辐射诱导的声学原理应用于三个主要研究领域：线性加速器光子束剂量测定，质子治疗范围验证和放射成像。本文介绍了电离辐射感生声波的理论背景，总结了该领域的最新进展，并提供了如何电离辐射感生声波的检测可用于光子治疗中的相对和体内剂量测定，质子治疗中的布拉格峰的定位，以及作为一种低剂量医学成像模式的前景。这些技术的临床实施的未来前景和挑战进行了讨论。
Acoustic waves are induced via the thermoacoustic effect in objects exposed to a pulsed beam of ionizing radiation. This phenomenon has interesting potential applications in both radiotherapy dosimetry and treatment guidance as well as low-dose radiological imaging. After initial work in the field in the 1980s and early 1990s, little research was done until 2013 when interest was rejuvenated, spurred on by technological advances in ultrasound transducers and the increasing complexity of radiotherapy delivery systems. Since then, many studies have been conducted and published applying ionizing radiation-induced acoustic principles into three primary research areas: Linear accelerator photon beam dosimetry, proton therapy range verification, and radiological imaging. This review article introduces the theoretical background behind ionizing radiation-induced acoustic waves, summarizes recent advances in the field, and provides an outlook on how the detection of ionizing radiation-induced acoustic waves can be used for relative and invivo dosimetry in photon therapy, localization of the Bragg peak in proton therapy, and as a low-dose medical imaging modality. Future prospects and challenges for the clinical implementation of these techniques are discussed.