Fabrication of Low-Cost Patient-Specific Vascular Models for Particle Image Velocimetry
Fabrication of Low-Cost Patient-Specific Vascular Models for Particle Image Velocimetry
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DOI：
10.1007/s13239-019-00417-2
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发表时间：
2019-09-01
影响因子：
1.8
通讯作者：
Roldan-Alzate, Alejandro
中科院分区：
文献类型：
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作者：
Ruedinger, Katrina L.;Medero, Rafael;Roldan-Alzate, Alejandro
目的粒子图像测速技术（Particle image velocimetry，PIV）是一种通过光学测量速度分量来分析流体速度场的体外实验技术，在研究各种血管区域内的流动动力学方面越来越受欢迎。然而，由于模型和流体的折射率匹配的重要性，为PIV创建患者特定的清晰模型可能是困难和昂贵的。我们的目标是实施和测试使用聚乙烯醇（PVA）在一个失芯铸造技术，以创建低成本，患者特定的模型PIV。方法利用Mimics/3 Matic对患者血管解剖结构进行三维数字减影，并进行分割和处理。核心是用PVA 3D打印的，并用80：20的水：胶水混合物进行后处理，以使表面光滑。使用两种硅胶Sylgard 184和Solaris封装模型，并使用温水溶解PVA芯。使用计算机断层扫描来评价几何精度，使用模型中的周长和表面差异。结果最终硅胶模型和预期STL打印几何结构之间沿入口中心线的周长沿着的平均几何差异和动脉瘤的平均表面差异在统计学上不显著（分别为0.6 mm，95% CI [- 1.4，2.8]和0.3 mm，95% CI [- 0.1，0.7]）。每个模型内的粒子照明都是成功的。一个10 cm x 10 cm x 5 cm模型的成本为69美元。结论该技术成功地实现并测试了PVA在失芯铸造技术中的使用，以创建用于PIV实验的低成本、患者特异性体外模型。
Purpose Particle image velocimetry (PIV), an in vitro experimentation technique that optically measures velocity components to analyze fluid velocity fields, has become increasingly popular to study flow dynamics in various vascular territories. However, it can be difficult and expensive to create patient-specific clear models for PIV due to the importance of refractive index matching of the model and the fluid. We aim to implement and test the use of poly-vinyl alcohol (PVA) in a lost-core casting technique to create low-cost, patient-specific models for PIV. Methods Anonymized patient vascular anatomies were segmented and processed in Mimics/3Matic to create patient-specific cores from 3D digital subtraction angiographies. The cores were 3D-printed with PVA and post-processed with a 80:20 water:glue mixture to smooth the surface. Two silicones, Sylgard 184 and Solaris, were used to encapsulate the model and the PVA core was dissolved using warm water. Computed tomography scans were used to evaluate geometric accuracy using circumferences and surface differences in the model. Results Mean geometric differences in circumference along the inlet centerline and the mean surface difference in the aneurysm between the final Silicone Model and the desired STL Print geometry were statistically insignificant (0.6 mm, 95% CI [- 1.4, 2.8] and 0.3 mm 95% CI [- 0.1, 0.7], respectively). Particle illumination within each model was successful. The cost of one 10 cm x 10 cm x 5 cm model was $69. Conclusion This technique was successful to implement and test the use of PVA in a lost-core casting technique to create low-cost, patient-specific in vitro models for PIV experimentation.