Fundus autofluorescence and central serous chorioretinopathy
Fundus autofluorescence and central serous chorioretinopathy
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DOI：
10.1016/j.ophtha.2005.01.003
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发表时间：
2005-05-01
期刊：
影响因子：
13.7
通讯作者：
Klancnik, JM
中科院分区：
文献类型：
--
作者：
Spaide, RF;Klancnik, JM
目的：研究中心性浆液性脉络膜视网膜病变患者的自体荧光特征。设计：观察病例系列。参与者：30例连续患者在私人转诊practice.Methods：患者进行自体荧光摄影，眼底摄影，荧光素血管造影，光学相干断层扫描（OCT）成像。从以中央凹为中心的100像素直径的圆获得灰度值的平均值和标准差（SD），并用后极的自发荧光水平进行标准化。共有30名患者，23名男性（76.7%）和7名女性（23.3%），中位视力（VA）为20/25，范围为20/15至20/400。包括个体固定效应的逐步线性回归发现，标准化中央黄斑自发荧光（P 0.001）、中央凹色素斑（P = 0.045）、OCT检测到的中央凹下液体（P = 0.033）和中央黄斑自发荧光的SD（P = 0.025）产生了预测VA的高度显著性模型（R-2 = 0.92，P 0.001）。OCT显示，自体荧光水平的增加与视网膜外表面的物质积累相关。中央黄斑自体荧光减少，特别是在中央地图状视网膜色素上皮萎缩的眼睛中，与视力差相关。这项研究确定了发生在中心性浆液性脉络膜视网膜病变中的具有明确模式的自发荧光变化可以以非侵入性方式测量，并且该信息可用于估计由中心性浆液性脉络膜视网膜病变引起的损伤，具有高度的统计学显著性。我们推测，材料的外表面上的升高的视网膜可能代表积累的感光细胞外节继发于缺乏直接的附着和吞噬的视网膜色素上皮细胞。© 2005年由美国眼科学会。
Purpose: To investigate the autofluorescence characteristics in patients with central serous chorioretinopathy.Design: Observational case series.Participants: Thirty consecutive patients examined in a private referral practice.Methods: Patients were imaged with autofluorescence photography, fundus photography, fluorescein angiography, and optical coherence tomography (OCT). The mean and standard deviation (SD) of the grayscale values from a 100-pixel-diameter circle centered on the fovea were obtained and normalized with the level of autofluorescence of the posterior pole.Results: There were 30 patients, 23 male (76.7%) and 7 female (23.3%), with a median visual acuity (VA) of 20/25 and a range of 20/15 to 20/400. Stepwise linear regression that included individual fixed effects found that normalized central macular autofluorescence (P < 0.001), pigment mottling in the fovea (P = 0.045), subfoveal fluid detected by OCT (P = 0.033), and the SD of the central macular autofluorescence (P = 0.025) produced a highly significant model (R-2 = 0.92, P&MLT; 0.001) predicting VA. Increasing levels of autofluorescence were correlated with accumulation of material on the outer surface of the retina as seen by OCT. Decreased central macular autofluorescence, particularly in those eyes with central geographic retinal pigment epithelial atrophy, was associated with poor VA.Conclusions: This study established that autofluorescence changes occurring in central serous chorioretinopathy with explicit patterns can be measured in a noninvasive manner, and this information can be used to estimate the damage induced by central serous chorioretinopathy with a high degree of statistical significance. We hypothesize that the material on the outer surface of the elevated retina may represent accumulation of photoreceptor outer segments secondary to the lack of direct apposition and phagocytosis by the retinal pigment epithelium. © 2005 by the American Academy of Ophthalmology.