SLEEP DISTURBANCE AND DEPRESSIVE AFFECT IN PATIENTS TREATED WITH HAEMODIALYSIS
SLEEP DISTURBANCE AND DEPRESSIVE AFFECT IN PATIENTS TREATED WITH HAEMODIALYSIS
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DOI：
10.1111/jorc.12188
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发表时间：
2017-03-01
影响因子：
1.9
通讯作者：
Cukor, Daniel
中科院分区：
文献类型：
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作者：
Maung, Stephanie;El Sara, Ammar;Cukor, Daniel
背景：睡眠障碍和抑郁是终末期肾病患者的常见症状。这些合并症有显著重叠，并加重了发病率和死亡率负担。这种重叠对最佳临床评估和治疗提出了挑战。本研究的目的是评估维持性血液透析患者的睡眠障碍的患病率，并评估抑郁affect.Objectives的影响：这是一个单一的网站，单组，横断面研究69英语为母语的患者进行维持性血液透析。自我报告的评估包括睡眠质量（匹兹堡睡眠质量指数）、抑郁（贝克抑郁量表）、日间嗜睡（埃普沃思嗜睡量表）、透析特定睡眠问卷和标准实验室值。没有客观的睡眠信息collected.Method：所有参与者都进行了良好的透析，并代表了所有四个每日轮班。58%的人报告了临床上显著的睡眠困难，白天嗜睡程度升高但低于阈值。平均抑郁情绪也升高，但亚诊断和正相关的年龄增加。结果：参与者得分高于抑郁症的诊断阈值有显着更不安的睡眠质量，更多的白天嗜睡，并有更多的睡眠问题，由于不宁腿综合征比人与最小的抑郁情绪。睡眠质量差在维持性血液透析患者中普遍存在，并与日间嗜睡增加相关。抑郁症进一步加剧了这种关系，并与白天嗜睡和不宁腿综合征的增加显著相关。
Background: Sleep disorders and depression are prevalent conditions in patients with end-stage kidney disease. These co-morbidities have significant overlap and compounded morbidity and mortality burden. This overlap presents challenges to optimal clinical assessment and treatment. The goal of this study was to assess the prevalence of sleep disturbance in patients on maintenance haemodialysis, and to assess the impact of depressive affect.Objectives: This was a single-site, single group, cross-sectional study of 69 English-speaking patients undergoing maintenance haemodialysis. Self-reported assessments included those of sleep quality (Pittsburgh Sleep Quality Index), depression (Beck Depression Inventory), daytime sleepiness (Epworth's Sleepiness Scale), a dialysis-specific sleep questionnaire, and standard laboratory values. No objective sleep information was collected.Method: All participants were well dialysed, and represented all four daily shifts. Fifty-eight per cent reported clinically significant sleep difficulty, with elevated yet sub-threshold daytime sleepiness. Mean depressive affect was also elevated, yet sub-diagnostic and was positively correlated with increased age.Results: Participants scoring above the diagnostic threshold for depression had significantly more disturbed sleep quality, more daytime sleepiness and had more problems sleeping due to restless leg syndrome than people with minimal depressive affect.Conclusion: Poor sleep quality is prevalent in patients on maintenance haemodialysis, and is associated with increased daytime sleepiness. Depression further compounds this relationship, and is significantly associated with increased daytime sleepiness and restless leg syndrome.