INDIVIDUAL, BUT NOT SIMULTANEOUS, GLUCAGON AND CHOLECYSTOKININ INFUSIONS INHIBIT FEEDING IN MEN
INDIVIDUAL, BUT NOT SIMULTANEOUS, GLUCAGON AND CHOLECYSTOKININ INFUSIONS INHIBIT FEEDING IN MEN
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DOI：
10.1152/ajpregu.1992.262.6.r975
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发表时间：
1992-06-01
影响因子：
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通讯作者：
HINTON, V
中科院分区：
文献类型：
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作者：
GEARY, N;KISSILEFF, HR;HINTON, V
正常体重男性在预食500毫升番茄汤后15分钟开始静脉注射胰高血糖素和八肽缩胆囊素(CCK-8)(1毫升/分钟，持续10分钟)或联合静脉滴注10分钟，5分钟后开始进食番茄酱通心粉和牛肉午餐。输注大约3 mg·kg~(-1)·min~(-1)的胰高血糖素或大约2 mg·kg~(-1)·min~(-1)CCK-8可以减少试餐的份量。然而，同时注入这些多肽的剂量减少的餐量小于这些多肽单独作用的总和。输注大约1.5 ng·kg~(-1)·min~(-1)的胰高血糖素或大约1 ng·kg~(-1)·min~(-1)CCK-8对膳食大小没有单独或交互作用的影响。心理物理评分未能检测到任何输液后的非特异性副作用。外源胰高血糖素和CCK-8均可减少食量而无副作用，这表明这些多肽可能参与了对人类食欲的生理控制；同时注射它们导致食量的低于添加剂的减少，这表明它们可以相互拮抗。
Pancreatic glucagon and cholecystokinin octapeptide (CCK-8) were intravenously infused (1 ml/min for 10 min) alone or in combination beginning 15 min after normal-weight men had eaten a 500-ml tomato soup preload and 5 min before they were served a lunch of macaroni and beef with tomato sauce. Infusion of approximately 3 ng.kg-1.min-1 glucagon or approximately 2 ng.kg-1.min-1 CCK-8 each reduced test meal size. However, simultaneous infusion of these peptide doses reduced meal size less than the sum of the peptides' individual effects. Infusions of approximately 1.5 ng.kg-1.min-1 glucagon or approximately 1 ng.kg-1.min-1 CCK-8 had neither individual nor interactive effects on meal size. Psychophysical ratings failed to detect nonspecific side effects after any of the infusions. That exogenous glucagon and CCK-8 each reduced meal size without side effects suggests that these peptides may participate in the physiological control of human appetite; that their simultaneous infusion resulted in an infra-additive reduction in meal size suggests that they can interact antagonistically.