Dendritic Cells in Systemic Lupus Erythematosus: From Pathogenic Players to Therapeutic Tools.
Dendritic Cells in Systemic Lupus Erythematosus: From Pathogenic Players to Therapeutic Tools.
复制标题
系统性红斑狼疮中的树突状细胞：从致病因子到治疗工具
DOI：
10.1155/2016/5045248
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发表时间：
2016
影响因子：
4.6
通讯作者：
Janssen EM
中科院分区：
文献类型：
--
作者：
Klarquist J;Zhou Z;Shen N;Janssen EM
系统性红斑狼疮(SLE)是一种具有多种临床表现的多因素系统性自身免疫性疾病。系统性红斑狼疮被认为是由于免疫反应失调，CD4T细胞和B细胞对无处不在的自身抗原失去耐受性，以及随后产生抗核抗体和其他自身反应抗体所致。最近的研究将狼疮的发生与树突状细胞(DC)亚群的改变联系在一起，包括DC亚群频率和定位的改变，MDCs和PDCs的过度激活，以及DC的功能缺陷。在这里，我们讨论DC功能障碍在SLE发病机制中的作用，重点是DC作为介入治疗的靶点。
System lupus erythematosus (SLE) is a multifactorial systemic autoimmune disease with a wide variety of presenting features. SLE is believed to result from dysregulated immune responses, loss of tolerance of CD4 T cells and B cells to ubiquitous self-antigens, and the subsequent production of anti-nuclear and other autoreactive antibodies. Recent research has associated lupus development with changes in the dendritic cell (DC) compartment, including altered DC subset frequency and localization, overactivation of mDCs and pDCs, and functional defects in DCs. Here we discuss the current knowledge on the role of DC dysfunction in SLE pathogenesis, with the focus on DCs as targets for interventional therapies.