Executive function differences in multiple system atrophy and Parkinson's disease
Executive function differences in multiple system atrophy and Parkinson's disease
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DOI：
10.1016/s1353-8020(02)00050-0
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发表时间：
2003-03-01
影响因子：
4.1
通讯作者：
Destee, A
中科院分区：
文献类型：
--
作者：
Dujardin, K;Defebvre, L;Destee, A
本研究的目的是评估多系统萎缩（MSA）和帕金森病（PD）患者的执行功能，寻找具体差异，并考虑运动障碍和疾病持续时间。将11名MSA患者的表现与12名健康对照者和两组12名PD患者的表现进行比较，其中一组与运动症状的严重程度相匹配，另一组与疾病持续时间相匹配。与健康对照相比，MSA和PD患者均表现出执行功能障碍，但MSA患者的损害更为严重和弥漫性。本研究表明，尽管有证据表明MSA和PD的执行功能存在一些差异，但标准神经心理学检查对这两种综合征的鉴别诊断的贡献仍然有限。(C) 2002 Elsevier Science Ltd.版权所有。
The aim of the present study was to assess executive function in patients with multiple system atrophy (MSA) and Parkinson's disease (PD) looking for specific differences and considering motor disability and disease duration.Performance of 11 MSA patients was compared to that of 12 healthy controls and two groups of 12 PD patients, one matched with respect to the severity of motor symptoms and the other with respect to disease duration.Compared to healthy controls, MSA and PD patients both presented executive dysfunction but, in MSA, the impairment was more severe and diffuse.This study suggests that despite the evidence of some differences in executive function in MSA and PD, the contribution of standard neuropsychological examination to the differential diagnosis of both syndromes remains still limited. (C) 2002 Elsevier Science Ltd. All rights reserved.