Lectins, Interconnecting Proteins with Biotechnological/Pharmacological and Therapeutic Applications.
Lectins, Interconnecting Proteins with Biotechnological/Pharmacological and Therapeutic Applications.
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DOI：
10.1155/2017/1594074
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Correia MT
中科院分区：
文献类型：
--
作者：
Coelho LC;Silva PM;Lima VL;Pontual EV;Paiva PM;Napoleão TH;Correia MT
凝集素是广泛用于生物医学应用的蛋白质，具有通过碳水化合物结合位点识别碳水化合物的特性，其识别附着于细胞表面的聚糖、糖缀合物或游离糖，检测异常细胞和与疾病相关的生物标志物。这些凝集素的能力促进了免疫性疾病、创伤和癌症的实验性治疗的有趣结果。从病毒、微生物、藻类、动物和植物中获得的凝集素被报道为体内和体外的调节剂和工具标记物;这些分子还在诱导有丝分裂和免疫应答中发挥作用，有助于解决感染和炎症。凝集素通过诱导伤口上皮再生和愈合而发挥愈合作用。一些凝集素在低浓度下已成为抗病毒、真菌、细菌和蠕虫的有效试剂。凝集素介导的生物粘附是药物释放系统开发的一个有趣特性。凝集素组织化学和基于凝集素的生物传感器可用于检测转化的组织和与疾病发生相关的生物标志物;已报道的抗肿瘤凝集素有希望用于癌症治疗。在这里，我们从不同来源的凝集素与一些生物学效应和生物技术的潜力，在疾病的诊断和治疗，突出了许多进展，在这个不断增长的领域。
Lectins are proteins extensively used in biomedical applications with property to recognize carbohydrates through carbohydrate-binding sites, which identify glycans attached to cell surfaces, glycoconjugates, or free sugars, detecting abnormal cells and biomarkers related to diseases. These lectin abilities promoted interesting results in experimental treatments of immunological diseases, wounds, and cancer. Lectins obtained from virus, microorganisms, algae, animals, and plants were reported as modulators and tool markers in vivo and in vitro; these molecules also play a role in the induction of mitosis and immune responses, contributing for resolution of infections and inflammations. Lectins revealed healing effect through induction of reepithelialization and cicatrization of wounds. Some lectins have been efficient agents against virus, fungi, bacteria, and helminths at low concentrations. Lectin-mediated bioadhesion has been an interesting characteristic for development of drug delivery systems. Lectin histochemistry and lectin-based biosensors are useful to detect transformed tissues and biomarkers related to disease occurrence; antitumor lectins reported are promising for cancer therapy. Here, we address lectins from distinct sources with some biological effect and biotechnological potential in the diagnosis and therapeutic of diseases, highlighting many advances in this growing field.