Respiratory infectious phenotypes in acute exacerbation of COPD: an aid to length of stay and COPD Assessment Test.
Respiratory infectious phenotypes in acute exacerbation of COPD: an aid to length of stay and COPD Assessment Test.
复制标题
COPD 急性加重时的呼吸道感染表型：有助于延长住院时间和 COPD 评估测试
DOI：
10.2147/copd.s92160
复制
发表时间：
2015
影响因子：
2.8
通讯作者：
Fei GH
中科院分区：
文献类型：
--
作者：
Dai MY;Qiao JP;Xu YH;Fei GH
探讨COPD急性加重期（AECOPD）患者呼吸道感染表型及其对住院时间（LOS）和COPD评估试验（CAT）量表的影响。我们将81例符合条件的患者分为细菌感染、病毒感染、合并感染和非感染组。呼吸道病毒检测采用液体微珠阵列xTAG呼吸道病毒检测试剂盒，而细菌感染则采用常规痰培养进行研究。记录LOS和CAT以及人口统计学信息。在38名受试者中检测到病毒，17名受试者中检测到细菌，其中7名受试者两者都有。流感病毒是最常见的分离病毒，其次是肠道病毒/鼻病毒、冠状病毒、博卡病毒、偏肺病毒、1型、2型、3型和4型副流感病毒以及呼吸道合胞病毒。痰细菌学分析显示铜绿假单胞菌是最常见的细菌，其次是鲍曼不动杆菌、克雷伯菌、大肠埃希菌和肺炎链球菌。合并感染组LOS最长，CAT评分最高。CAT评分与LOS呈正相关。呼吸道感染是COPD加重的常见病因。呼吸道合并感染可能是导致更严重急性加重和更长LOS的决定因素。CAT评分可能是AECOPD患者更长LOS的预测因子。
To investigate the respiratory infectious phenotypes and their impact on length of stay (LOS) and the COPD Assessment Test (CAT) Scale in acute exacerbation of COPD (AECOPD). We categorized 81 eligible patients into bacterial infection, viral infection, coinfection, and non-infectious groups. The respiratory virus examination was determined by a liquid bead array xTAG Respiratory Virus Panel in pharyngeal swabs, while bacterial infection was studied by conventional sputum culture. LOS and CAT as well as demographic information were recorded. Viruses were detected in 38 subjects, bacteria in 17, and of these, seven had both. Influenza virus was the most frequently isolated virus, followed by enterovirus/rhinovirus, coronavirus, bocavirus, metapneumovirus, parainfluenza virus types 1, 2, 3, and 4, and respiratory syncytial virus. Bacteriologic analyses of sputum showed that Pseudomonas aeruginosa was the most common bacteria, followed by Acinetobacter baumannii, Klebsiella, Escherichia coli, and Streptococcus pneumoniae. The longest LOS and the highest CAT score were detected in coinfection group. CAT score was positively correlated with LOS. Respiratory infection is a common causative agent of exacerbations in COPD. Respiratory coinfection is likely to be a determinant of more severe acute exacerbations with longer LOS. CAT score may be a predictor of longer LOS in AECOPD.