Stress puts TIA on TOP
Stress puts TIA on TOP
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DOI：
10.1101/gad.17838411
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发表时间：
2011-10-15
影响因子：
10.5
通讯作者：
Anderson, Paul
中科院分区：
文献类型：
--
作者：
Ivanov, Pavel;Kedersha, Nancy;Anderson, Paul
在营养有限的条件下，真核细胞以一种减缓生长但提高存活率的方式重新编程蛋白质表达。最近的数据牵连应力颗粒，离散的细胞质病灶，其中未翻译的mRNP在应力过程中组装，在这个过程中。在2011年10月1日的Genes & Development期刊中，Damgaard和Lykke-Andersen（第2057-2068页）提供了对结构相关的应激颗粒蛋白TIA-1和TIAR对携带5 '末端寡嘧啶段（5' TOP）的特定mRNA子集的调节机制的见解。
Under conditions of limited nutrients, eukaryotic cells reprogram protein expression in a way that slows growth but enhances survival. Recent data implicate stress granules, discrete cytoplasmic foci into which untranslated mRNPs are assembled during stress, in this process. In the October 1, 2011, issue of Genes & Development, Damgaard and Lykke-Andersen (p. 2057-2068) provide mechanistic insights into the regulation of a specific subset of mRNAs bearing 5'-terminal oligopyrimidine tracts (5'TOPs) by the structurally related stress granule proteins TIA-1 and TIAR.