Matrix metalloproteinases.
Matrix metalloproteinases.
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DOI：
10.1007/978-3-0348-0364-9_1
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发表时间：
2012-01-01
影响因子：
--
通讯作者：
Mechirova, Viola
中科院分区：
文献类型：
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作者：
Vargova, Viola;Pytliak, Marek;Mechirova, Viola
细胞外基质的重塑对于许多生理（细胞迁移、增殖、生长和发育）和病理（心脏重塑、癌发生、转移等）过程至关重要。事件因此，细胞与细胞外基质之间的相互作用在生物体的正常发育和分化以及许多病理状态中起着关键作用。细胞外基质的变化受蛋白水解酶系统的调节，蛋白水解酶系统负责大量细胞外基质组分的蛋白水解。基质金属蛋白酶（MMP）代表ECM中的主要调节蛋白酶组。基质金属蛋白酶改变组织结构完整性的能力对于正常生理和病理的某些方面是必不可少的。加工分子如生长因子、受体、粘附分子、其他蛋白酶和蛋白酶抑制剂的能力使得MMP成为细胞微环境中生理和病理事件的有效控制器。MMPs的过度激活与许多疾病状态有关。
Remodeling of extracellular matrix is crucial for many physiological (cell migration, proliferation, growth, and development) and pathological (remodeling of heart, carcinogenesis, metastasis, etc.) events. Thus, the interaction between cells and extracellular matrix plays a key role in normal development and differentiation of organism and many pathological states as well. Changes in extracellular matrix are regulated by a system of proteolytic enzymes that are responsible for proteolysis of huge quantity of extracellular matrix components. Matrix metalloproteinases (MMPs) represent the main group of regulating proteases in ECM. Ability of matrix metalloproteinases to modify the structural integrity of tissues is essential for certain aspects of normal physiology and pathology. The ability to process molecules such as growth factors, receptors, adhesion molecules, other proteinases, and proteinase inhibitors makes MMPs potent controllers of physiological and pathological events in the cell microenvironment. Overactivation of MMPs has been implicated in numerous disease states.