Serum lipocalin-2 levels positively correlate with coronary artery disease and metabolic syndrome.
Serum lipocalin-2 levels positively correlate with coronary artery disease and metabolic syndrome.
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血清脂质运载蛋白 2 水平与冠状动脉疾病和代谢综合征呈正相关
DOI：
10.1186/1475-2840-12-176
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发表时间：
2013-12-21
影响因子：
9.3
通讯作者：
Jia W
中科院分区：
文献类型：
--
作者：
Ni J;Ma X;Zhou M;Pan X;Tang J;Hao Y;Lu Z;Gao M;Bao Y;Jia W
背景脂质运载蛋白-2（LCN 2）细胞因子，主要是已知的人类中性粒细胞颗粒的蛋白质，最近被报道与代谢和炎症性疾病有关。为探讨血清LCN 2水平与冠状动脉病变的关系，采用双抗体夹心酶联免疫法测定261例冠状动脉造影患者血清LCN 2水平。人口（169名男性和92名绝经后女性）和临床收集代谢综合征（MS）、甘油三酯（TG）和C反应蛋白（CRP）水平，分析CAD的独立危险因素（CAD：188，非CAD：73）和血清LCN 2水平通过多元逻辑回归和多元逐步回归分析，结果男性血清LCN 2水平显著高于女性，（37.5（27.4-55.4））与妇女：28.2（18.7-45.9）ng/mL，p< 0.01）和CAD男性（39.2（29.3-56.5）vs.非CAD男性：32.7（20.5-49.7）ng/mL，p< 0.05），与男性冠心病呈显著正相关（OR = 2.218，95%可信区间：1.017-4.839）。同样，MS男性患者的血清LCN 2水平显著更高（40.2（31.9-59.4）vs.非MS：32.0（21.7-47.6）ng/mL，p< 0.01），并与MS组分数量呈显著正相关（趋势p < 0.05）。在女性中没有发现显著差异或相关性。TG和中性粒细胞（标准β = 0.238和0.173）是男性血清LCN 2水平的独立影响因素，女性仅中性粒细胞（标准β = 0.286）影响LCN 2水平（p < 0.05）。
BackgroundThe lipocalin-2 (LCN2) cytokine, primarily known as a protein of the granules of human neutrophils, has been recently reported to be implicated in metabolic and inflammatory disorders. This study was designed to evaluate the relationship between serum LCN2 levels and coronary artery disease (CAD).MethodsSerum LCN2 levels of 261 in-patients who underwent coronary angiography were measured by sandwich enzyme immunoassay. Demographic (169 men and 92 postmenopausal women) and clinical (metabolic syndrome (MS), triglyceride (TG) and C-reactive protein (CRP) levels) characteristics were collected to assess independent factors of CAD (CAD: 188 and non-CAD: 73) and serum LCN2 levels by multiple logistic regression and multivariate stepwise regression analyses, respectively.ResultsSerum LCN2 levels were significantly higher in men (37.5 (27.4-55.4) vs. women: 28.2 (18.7-45.9) ng/mL,p< 0.01) and men with CAD (39.2 (29.3-56.5) vs. non-CAD men: 32.7 (20.5-49.7) ng/mL,p< 0.05), and showed significant positive correlation with CAD in men (odds ratio = 2.218, 95% confidence interval: 1.017-4.839). Similarly, serum LCN2 levels were significantly higher in men with MS (40.2 (31.9-59.4) vs. non-MS: 32.0 (21.7-47.6) ng/mL,p< 0.01) and showed a significant positive correlation with the number of MS components (pfor trend < 0.05). No significant differences or correlations were seen in women. TG and neutrophils (standard β = 0.238 and 0.173) were independent factors of serum LCN2 levels in men, and only neutrophils (standard β = 0.286) affected levels in women (allp< 0.05).ConclusionsIncreased serum LCN2 levels are positively correlated with the presence of CAD and MS in a Chinese cohort.
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影响因子：
--
作者：
Hutcheson R;Rocic P
通讯作者：
Rocic P
DOI：
10.1161/01.atv.0000193567.88685.f4
发表时间：
2006-01-01
影响因子：
8.7
作者：
Hemdahl, AL;Gabrielsen, A;Hansson, GK
通讯作者：
Hansson, GK
影响因子：
5.3
作者：
Paulsson, Josefin;Dadfar, Elham;Lundahl, Joachim
通讯作者：
Lundahl, Joachim
影响因子：
8.2
作者：
MATTHEWS, DR;HOSKER, JP;TURNER, RC
通讯作者：
TURNER, RC
影响因子：
9.3
作者：
Wang, Yu;Lam, Karen S. L.;Xu, Aimin
通讯作者：
Xu, Aimin