Diabetic Mice Show an Aggravated Course of Herpes-Simplex Virus–Induced Facial Nerve Paralysis
Diabetic Mice Show an Aggravated Course of Herpes-Simplex Virus–Induced Facial Nerve Paralysis
复制标题
糖尿病小鼠表现出单纯疱疹病毒引起的面神经麻痹的加重过程
作者：
S. Esaki;K. Yamano;Junpei Kiguchi;S. Katsumi;S. Keceli;H. Okamoto;F. Goshima;H. Kimura;Y. Nishiyama;S. Murakami
贝尔麻痹与糖尿病高度相关的假设。背景糖尿病患者贝尔麻痹的病因尚不完全清楚。糖尿病性单神经病变或单纯疱疹病毒1型（HSV-1）的再激活可能是糖尿病患者面瘫的原因。我们以前曾报道过在接种HSV-1的小鼠中出现一过性和同侧面瘫。在这项研究中，我们研究了HSV-1在糖尿病小鼠的神经发病机制，以澄清贝尔麻痹和糖尿病之间的关系。方法比较糖尿病和非糖尿病小鼠接种HSV-1后面瘫的发生率和病程。通过腹腔注射链脲佐菌素制备糖尿病小鼠。通过电生理和组织病理学检查评估面神经损伤。结果与非糖尿病组相比，糖尿病组小鼠面神经麻痹的发生率明显增加。电生理检查和组织病理学检查也显示糖尿病组面神经损害较对照组严重。结论HSV-1感染在糖尿病患者中的加重过程提示HSV-1可能是糖尿病患者面瘫发病率增高的主要原因。
Hypothesis Bell’s palsy is highly associated with diabetes mellitus. Background The cause of Bell’s palsy in diabetes mellitus is not completely understood. Diabetic mononeuropathy or reactivation of herpes simplex virus type 1 (HSV-1) may be responsible for the facial paralysis seen in diabetic patients. We previously reported transient and ipsilateral facial paralysis in mice inoculated with HSV-1. In this study, we examined the neuropathogenesis of HSV-1 in diabetic mice to clarify the relationship between Bell’s palsy and diabetes mellitus. Methods We compared the incidence and course of facial paralysis after HSV-1 inoculation in diabetic and nondiabetic mice groups. Diabetic mice were prepared by intraperitoneal streptozotocin injection. Facial nerve damage was assessed by electrophysiologic and histopathologic examinations. Results Compared with the nondiabetic group, the incidence of facial nerve paralysis was significantly increased in the diabetic mice. Electrophysiologic examinations and histopathologic changes also revealed that the facial nerve damage was more severe in the diabetic group. Conclusion The aggravated course of HSV-1 infection in diabetes suggests that HSV-1 may be the main causative factor for the increased incidence of facial paralysis in diabetic patients.
DOI：
10.1073/pnas.89.6.2218
发表时间：
1992-03
影响因子：
11.1
作者：
J. Poduslo;G. Curran
通讯作者：
J. Poduslo;G. Curran
影响因子：
158.5
作者：
Gilden, DH
通讯作者：
Gilden, DH