A AgOAc/quinine-derived aminophosphine complex as an efficient catalyst for diastereo- and enantioselective 1,3-dipolar cycloaddition of alpha,beta-unsaturated 7-azaindoline amides and azomethine ylides
A AgOAc/quinine-derived aminophosphine complex as an efficient catalyst for diastereo- and enantioselective 1,3-dipolar cycloaddition of alpha,beta-unsaturated 7-azaindoline amides and azomethine ylides
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AgOAc/奎宁衍生的氨基膦络合物作为 α,β-不饱和 7-氮杂二氢吲哚酰胺和偶氮甲碱叶立德的非对映和对映选择性 1,3-偶极环加成的有效催化剂
DOI：
10.1039/c9qo00347a
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发表时间：
2019
影响因子：
5.4
通讯作者：
Yuan Wei-Cheng
中科院分区：
文献类型：
--
作者：
Zhang Yan-Ping;You Yong;Zhao Jian-Qiang;Zhou Xiao-Jian;Zhang Xiao-Mei;Xu Xiao-Ying;Yuan Wei-Cheng
奎宁衍生的氨基膦/Ag（I）配合物首次被证明是一种高效的催化剂，用于甲亚胺叶立德与具有挑战性的α，β-不饱和酰胺底物的高度立体选择性的1，3-偶极环加成反应。该方法合成了一系列具有四个相邻立体中心的高官能化吡咯烷衍生物，并具有良好的对映选择性和非对映选择性。
A quinine-derived aminophosphine/Ag(I) complex was firstly demonstrated to be an efficient catalyst for the highly stereoselective 1,3-dipolar cycloaddition of azomethine ylides with challenging α,β-unsaturated amide substrates. A wide range of densely functionalized pyrrolidine derivatives containing four contiguous stereogenic centers could be smoothly obtained with excellent diastereo- and enantioselectivities.