THE PROGNOSTIC-SIGNIFICANCE OF HISTOLOGIC REGRESSION IN CUTANEOUS MELANOMA
THE PROGNOSTIC-SIGNIFICANCE OF HISTOLOGIC REGRESSION IN CUTANEOUS MELANOMA
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DOI：
10.1097/00008390-199207000-00002
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发表时间：
1992-07-01
影响因子：
2.2
通讯作者：
URSO, C
中科院分区：
文献类型：
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作者：
BROGELLI, L;UMBERTO, MR;URSO, C
对201例I期皮肤黑色素瘤进行了回顾性评价，以研究组织学消退（67例）的预后意义。薄的黑色素瘤比厚的病变更频繁地显示出消退（48%小于或等于0.75 mm vs 12% > 3 mm）。平均无病间隔为33.53个月，在肿瘤消退和19.9在非肿瘤消退（p=0.07）：生存曲线之间的差异不显着（p=0.61）。13例（19.40%）肿瘤消退患者和40例（29.85%）非消退肿瘤患者发生转移。虽然我们观察到薄黑色素瘤的消退频率较高，但我们无法证明消退对无病间期和生存率的影响。
A retrospective evaluation of 201 stage I cutaneous melanomas was performed to investigate the prognostic significance of histological regression (present in 67 cases). Thin melanomas showed regression more frequently than thick lesions (48% less-than-or-equal-to 0.75 mm vs 12% > 3 mm). The mean disease-free interval was 33.53 months in regressing tumours and 19.9 in non-regressing tumours (p=0.07): differences between the survival curves were not significant (p=0.61). Metastases developed in 13 (19.40%) patients with regressing tumours and by 40 (29.85%) patients with non-regressing tumours. Although we observed a higher frequency of regression in thin melanomas we could not demonstrate an influence of regression on disease-free interval and survival.