Forces on adhesive contacts affect cell function
Forces on adhesive contacts affect cell function
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DOI：
10.1016/s0955-0674(98)80030-6
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发表时间：
1998-10-01
影响因子：
7.5
通讯作者：
Sheetz, MP
中科院分区：
文献类型：
--
作者：
Galbraith, CG;Sheetz, MP
作用在与细胞外基质 (ECM) 形成的粘附接触上的细胞力对细胞形状、活力、信号转导和运动有显着影响。在过去的两年中，研究确定了细胞扩散如何影响细胞活力以及细胞骨架组织。细胞骨架对 ECM 产生一定程度的张力，该张力与 ECM 刚度成正比。对 ECM 施加的张力的强度会影响细胞的迁移速度。
Cellular forces acting on the adhesive contacts made with the extracellular matrix (ECM) contribute significantly to cell shape, viability, signal transduction and motility. In the past two years, research has determined how cell spreading influences cell viability as well as cytoskeletal organization. The cytoskeleton generates a level of tension against the ECM that is proportional to ECM stiffness. The strength of this tension exerted against the ECM affects the migratory speed of the cell.