Evaluation of the relative dose response test for vitamin A nutriture in cirrhotics.
Evaluation of the relative dose response test for vitamin A nutriture in cirrhotics.
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肝硬化患者维生素 A 营养相对剂量反应试验的评价。
DOI：
10.1093/ajcn/34.10.2264
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
H. Al
中科院分区：
文献类型：
--
作者：
S. Mobarhan;R. M. Russell;B. Underwood;J. Wallingford;R. D. Mathieson;H. Al
口服450微克维生素（棕榈酸视黄酯）后5小时血清维生素A的升高被用来评估酒精性肝硬化患者的维生素A营养状况。该测试在21名住院男性患者和12名正常年龄和性别匹配的对照组中进行。以百分比表示的相对剂量反应（RDR）计算为A5 - A0/A5 X 100，其中A0 =空腹血清视黄醇水平，A5 =给药后5 h血清视黄醇。维生素A缺乏患者（血清视黄醇水平低于30 μ g/dl且暗适应试验异常或RDR大于或等于14%者）口服维生素A（10，000 μ g/d）4周，然后重复进行RDR和暗适应试验。在8名暗适应异常的患者中，平均+/- SEM RDR为21 +/- 9，而暗适应正常的患者为3 +/- 3%（p <0.01）。正常暗适应患者的RDR测试与12名正常年龄和性别匹配的对照受试者（正常RDR反应0至14%）没有差异。在发现维生素A缺乏的患者中，维生素A治疗导致平均+/- SEM RDR从21 +/- 9降至5 +/-2%。然而，这种下降未能达到统计学显著性（p = 0.06）。RDR测试似乎是有用的维生素A缺乏症的预测，即使是在患有晚期肝病的患者中。
The rise in serum vitamin A 5 h after a 450 microgram oral dose of the vitamin (retinyl palmitate) was used to assess vitamin A nutriture in patients with alcoholic cirrhosis. The test was carried out on 21 hospitalized male patients and 12 normal age and sex-matched control subjects. The relative dose response (RDR), expressed as percentage, was calculated as A5 - A0/A5 X 100 where A0 = the fasting serum retinol level and A5 = the serum retinol 5 h postdosing. Vitamin A-deficient patients (those with serum retinol levels less than 30 microgram/dl and an abnormal dark adaptation test or RDR greater than or equal to 14%) were treated with 4 wk of oral vitamin A (10,000 microgram/day), then repeat RDR and dark adaptation tests were carried out. Among eight cirrhotics with abnormal dark adaptation, the mean +/- SEM RDR was 21 +/- 9 versus 3 +/- 3% in patients with normal dark adaptation (p less than 0.01). RDR tests of patients with normal dark adaptation did not differ from those of 12 normal age and sex-matched control subjects (normal RDR response 0 to 14%). Among patients found to be vitamin A-deficient, treatment with vitamin A resulted in the mean +/- SEM RDR declining from 21 +/- 9 to 5 +/- 2%. However, this fall failed to reach statistical significance (p = 0.06). The RDR test appears to be useful as a predictor of vitamin A deficiency, even among patients with far advanced hepatic disease.