Scores for sequence searches and alignments
Scores for sequence searches and alignments
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DOI：
10.1016/s0959-440x(96)80055-8
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发表时间：
1996-06-01
影响因子：
6.8
通讯作者：
Henikoff, S
中科院分区：
文献类型：
--
作者：
Henikoff, S
每一种序列比较法都需要一组分数。对于蛋白质序列的比对，替代分数是基于氨基酸守恒和性质的模型，这些分数的矩阵在最近几年有了很大的改善。位置特定计分矩阵提供了能够检测细微相似性的序列家族的表示。综合评估可以有效地指导序列比对和搜索应用程序的分数选择，包括那些有助于预测蛋白质结构的应用程序。
Every sequence comparison method requires a set of scores. For aligning protein sequences, substitution scores are based on models of amino acid conservation and properties, and matrices of these scores have substantially improved in recent years. Position-specific scoring matrices provide representations of sequence families that are capable of detecting subtle similarities. Comprehensive evaluations can effectively guide the choice of scores for sequence alignment and searching applications, including those that aid in the prediction of protein structures.