The Effects of Monochromatic Illumination on Early Eye Development in Rhesus Monkeys
The Effects of Monochromatic Illumination on Early Eye Development in Rhesus Monkeys
复制标题
单色照明对恒河猴早期眼睛发育的影响。
DOI：
10.1167/iovs.13-12276
复制
发表时间：
2014-03-01
影响因子：
4.4
通讯作者：
Chu, Ren-Yuan
中科院分区：
文献类型：
--
作者：
Liu, Rui;Hu, Min;Chu, Ren-Yuan
目的
在灵长类动物的眼睛发育早期，纵向色差(LCA)对正视化的影响尚未被研究。我们研究了准单色光照对恒河猴屈光发育和眼睛生长的影响。
方法
在准单色蓝光(峰值455 nm)、红光(峰值610 nm)和白光(色温5000K)三种光照条件下饲养恒河猴幼猴51周。所有动物在指定的时间点分别使用睫状肌麻痹条纹检眼镜、角膜曲率计和A超进行屈光度、角膜屈光度和眼轴成分的生物测量。
结果
第51周，白光组和蓝光组与红光组相比，平均屈光度差分别达到1.71D和1.43D(P均<0.001)。红灯组的两只猴子在第16周患上了近视，而另外七只猴子在整个实验过程中一直保持着远视。蓝光组与白光组的平均屈光度差异无统计学意义。
结论
在对L视锥刺激敏感的一小部分恒河猴中，生命早期长波长光线的照射可能是近视发展的风险因素。
PURPOSE
Influence of longitudinal chromatic aberration (LCA) on emmetropization during early eye development has not been studied in primates. We investigated the effects of quasi-monochromatic lighting on refractive development and eye growth in rhesus monkeys.
METHODS
Infant rhesus monkeys were raised under one of three lighting conditions for 51 weeks: quasi-monochromatic blue light (peak 455 nm), red light (peak 610 nm), and white light (color temperature 5000 K). All animals underwent biometric measurements using cycloplegic streak retinoscope, keratometry, and A-scan ultrasonography for refraction, corneal power, and axial components, respectively, at designated time points.
RESULTS
At the 51st week, the mean difference in refraction of the white light and blue light groups, compared with that of the red light group, reached 1.71 diopters (D) and 1.43 D, respectively (both P < 0.001). Two monkeys in the red light group developed myopia at the 16th week, whereas the other seven remained hyperopic throughout the experiment. No significant difference in mean refraction was observed between the blue light group and white light group.
CONCLUSIONS
Illumination from long-wavelength light during early life could be a risk factor for the development of myopia in a small proportion of rhesus monkeys that are sensitive to L-cone stimulation.