Sero-Immunity and Serologic Response to Pandemic Influenza A (H1N1) 2009 Virus in Hong Kong
Sero-Immunity and Serologic Response to Pandemic Influenza A (H1N1) 2009 Virus in Hong Kong
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DOI：
10.1002/jmv.21895
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发表时间：
2010-11-01
影响因子：
12.7
通讯作者：
Lim, Wilina
中科院分区：
文献类型：
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作者：
Mak, Gannon C.;Choy, Perrin W. W.;Lim, Wilina
为研究香港对2009年甲型H1N1流感病毒的血清学反应，在爆发前和爆发后测量了免疫水平，并在实验室确诊病例的血清样本中测定了2009年甲型H1N1流感病毒抗体滴度。在37%的65岁以上的人群中存在2009年甲型H1N1流感大流行前病毒抗体，这表明以前接触过异源病毒株可能引发了交叉反应抗体。随着2009年甲型流感病毒大规模爆发，并于2009年9月达到高峰，不同年龄组别的免疫力水平出现变化，与香港人口的发病率一致。在具有轻度临床表现的个体中，24岁的个体对2009年甲型H1N1流感病毒的抗体应答较强;然而，
To study the serologic response to the new pandemic influenza A (H1N1) 2009 virus in Hong Kong, the level of immunity was measured before and after the occurrence of the outbreak, and the titer of antibody to the pandemic influenza A (H1N1) 2009 virus in serum samples of laboratory confirmed cases. The presence of pre-outbreak pandemic influenza A (H1N1) 2009 virus antibodies in 37% of individuals older than >65 years suggested previous exposures to heterologous virus strains may have elicited cross-reacting antibody. Following large outbreaks of pandemic influenza A 2009 virus that peaked in September 2009, there is a change in immunity level in various age groups consistent with the attack rates among population in Hong Kong. Among individuals with mild clinical presentation, the antibody response to pandemic influenza A (H1N1) 2009 virus was stronger in those individuals aged 24 years; however, the antibody level declined slower among individuals aged