Catecholamines, stress, and disease: a psychobiological perspective.
Catecholamines, stress, and disease: a psychobiological perspective.
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儿茶酚胺、压力和疾病：心理生物学的视角。
DOI：
10.1097/00006842-199611000-00007
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发表时间：
1996
影响因子：
3.3
通讯作者：
Gold,PE
中科院分区：
文献类型：
--
作者：
McCarty,R;Gold,PE
对压力刺激的生理反应与心身疾病发病之间的关系的研究多年来一直是一个非常感兴趣的领域。使用动物模型的研究作出了重大贡献，这一领域的调查，采取几种互补的approaches.MethodThree具体的研究策略，在我们的实验室将在这里强调。每个涉及有意识的研究，自由行为的animals.ResultsGenetically选择的动物已暴露于急性应激源，揭露神经内分泌和自主神经异常疾病易感性。此外，对老年动物的研究表明，对急性应激的过度生理反应可能是一些与年龄有关的病理的基础。最后，一系列的研究表明，实验室动物暴露于压力刺激可能会产生长期的，对这些受试者未来对相同或新型压力源的反应方式产生持久影响。结论这些发现说明了实验室动物研究如何有可能细化临床人群研究中提出的问题，并提供对潜在生理机制的深入了解疾病易感性的个体差异和适当治疗干预的发展。
ObjectiveResearch on the relationship between physiological responses to stressful stimulation and the onset of psychosomatic illnesses has been an area of intense interest for many years. Studies using animal models have contributed significantly to this field of inquiry by taking several complementary approaches.MethodThree specific research strategies taken in our laboratory will be highlighted here. Each involves studies in conscious, freely behaving animals.ResultsGenetically selected animals have been exposed to acute stressors to unmask neuroendocrine and autonomic abnormalities related to disease susceptibility. In addition, studies of aged animals suggest that exaggerated physiological responses to acute stress may underlie some age-related pathologies. Finally, a series of studies has revealed that exposure of laboratory animals to stressful stimulation may exert long-lasting influences on the ways in which these subjects respond in the future to the same or novel stressors.ConclusionsThese findings illustrate how studies with laboratory animals have the potential for refining the questions that are posed in research with clinical populations and for providing insight into the underlying physiological mechanisms of individual variability in disease susceptibility and the development of appropriate therapeutic interventions.