THE RESPONSE OF SELENIUM-DEFICIENT MICE TO CANDIDA-ALBICANS INFECTION
THE RESPONSE OF SELENIUM-DEFICIENT MICE TO CANDIDA-ALBICANS INFECTION
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DOI：
10.1093/jn/116.5.816
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发表时间：
1986-05-01
影响因子：
4.2
通讯作者：
ARTHUR, JR
中科院分区：
文献类型：
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作者：
BOYNE, R;ARTHUR, JR
本文观察了硒缺乏对小鼠白念珠菌感染反应的影响。当给缺硒和补硒小鼠静脉注射0.1ml 1 × 10 - 6的悬浮液时，105或5倍104 C.在0.9%无菌盐水中的白色念珠菌中，与补硒动物的7-8.5天相比，缺硒动物的死亡在2.5-3.5天后开始。进一步的研究表明，静脉注射1 × 10 - 6 μ g/ml后3天，105摄氏度白假丝酵母菌在缺硒小鼠肾脏（P < 0.001）、肝脏（P < 0.025）和脾脏（P < 0.01）中的检出率均显著高于补硒动物。硒缺乏也被证明会损害小鼠中性粒细胞杀死C.白念珠菌在体外试验中。这种功能缺陷可能与对C.白色念珠菌感染进行了讨论。J.营养116：816-822，1986.
The effects of selenium deficiency on the responses of Candida albicans infection were examined in mice. When selenium-deficient and selenium-supplemented mice were given i.v. injections of 0.1 ml suspensions of 1 .times. 105 or 5 .times. 104 C. albicans in 0.9% sterile saline, deaths in the selenium-deficient animals started after 2.5-3.5 d compared with 7-8.5 d in the selenium-supplemented animals. Further studies demonstrated that 3 d after an i.v. injection of 1 .times. 105 C. albicans, significantly more of the microorganisms were found in the kidneys (P < 0.001), livers (P < 0.025) and spleens (P < 0.01) of the selenium-deficient mice compared with the same organs of selenium-supplemented animals. Selenium deficiency was also demonstrated to impair the ability of mouse neutrophils to kill C. albicans in in vitro tests. The possible relationships of this defect in function to decreased resistance to C. albicans infection is discussed. J. Nutr. 116: 816-822, 1986.