Reversal of postmenopausal vertebral bone loss by oestrogen and progestogen: a double blind placebo controlled study
Reversal of postmenopausal vertebral bone loss by oestrogen and progestogen: a double blind placebo controlled study
复制标题
雌激素和孕激素逆转绝经后椎骨骨质流失：双盲安慰剂对照研究
作者：
N. Munk;S. P. Nielsen;E. Obel;P. B. Eriksen
由于对激素在绝经后骨质流失治疗中的作用的不确定性，在一项双盲安慰剂对照试验中，在绝经后早期妇女连续或顺序接受雌激素和孕激素联合治疗前后，通过吸收仪测量了椎体和前臂骨质流失。激素治疗可显著逆转椎体骨质流失。连续补充的椎体骨密度每年净增加6.4%，连续补充的椎体骨密度每年净增加5.4%；前臂骨密度的净增加较低（连续补充3.6%和连续补充3.7%）。在向所有绝经后妇女推荐以减少椎体挤压骨折发生率为目的的激素补充政策之前，需要对不同剂量和激素组合进行进一步研究，并持续数年。
Because of uncertainty about the place of hormones in the treatment of postmenopausal bone loss vertebral and forearm bone loss was measured by absorptiometry in early post-menopausal women before and after continuous or sequential treatment with combined oestrogen and progestogen in a double blind placebo controlled trial. Treatment with hormones significantly reversed the vertebral bone loss. The net gain in vertebral bone density amounted to 6·4% a year with continuous supplementation and 5·4% a year with sequential supplementation; the net gain in forearm bone density was lower (3·6% with continuous and 3·7% with sequential supplementation). Before a policy of supplementation with hormones can be recommended to all postmenopausal women with the aim of reducing the incidence of vertebral crush fractures further studies with different doses and combinations of hormones, administered over several years, are needed.
影响因子：
39.2
作者：
ETTINGER, B;GENANT, HK;CANN, CE
通讯作者：
CANN, CE