Clustering of metabolic factors and coronary heart disease
Clustering of metabolic factors and coronary heart disease
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DOI：
10.1001/archinte.159.10.1104
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发表时间：
1999-05-24
影响因子：
--
通讯作者：
D'Agostino, RB
中科院分区：
文献类型：
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作者：
Wilson, PWF;Kannel, WB;D'Agostino, RB
背景：常见代谢性冠状动脉疾病危险因素的聚类程度尚不清楚，聚类的前因尚未得到很好的研究，聚类对冠状动脉危险的影响尚未得到系统的评估。方法：前瞻性社区样本2406名男性和2569名女性，基线年龄为18至74岁。所考虑的6个代谢相关的危险因素是高密度脂蛋白胆固醇的最低性别特异性五分位数和体重指数、收缩压、甘油三酯、葡萄糖和血清总胆固醇的最高五分位数。结果：在基线时，危险因素总和以整数值表示，范围从0到6,3个或更多危险因素的集群发生的概率是预测概率的两倍。在调整年龄和肥胖水平后，16年内体重增加2.25公斤（5磅）与男性（+20%;P = 0.002）和女性（+37%;P = 0.002）的危险因素总和增加相关
Background: The degree of clustering for common metabolic coronary disease risk factors is not well known, the antecedents of clustering are not well studied, and the impact of such clusters on coronary risk has not been assessed systematically.Methods: Prospective community sample of 2406 men and 2569 women aged 18 to 74 years at baseline. The 6 metabolically linked risk factors considered were the lowest sex-specific quintile of high-density lipoprotein cholesterol and the highest quintiles of body mass index, systolic blood pressure, triglycerides, glucose, and serum total cholesterol.Results: At baseline the risk factor sum, represented as integer values, ranged from 0 to 6, and clusters of 3 or more risk factors occurred at twice the rate predicted by chance. After adjustment for age and obesity level, a 2.25-kg (5-lb) weight increase over 16 years was associated with an increased risk factor sum in men (+20%; P = .002) and women (+37%; P