Secondhand smoke exposure-induced nucleocytoplasmic shuttling of HMGB1 in a rat premature skin aging model
Secondhand smoke exposure-induced nucleocytoplasmic shuttling of HMGB1 in a rat premature skin aging model
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DOI：
10.1016/j.bbrc.2014.11.040
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发表时间：
2015-01-02
影响因子：
3.1
通讯作者：
Tancharoen, Salunya
中科院分区：
文献类型：
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作者：
Chaichalotornkul, Sirintip;Nararatwanchai, Thamthiwat;Tancharoen, Salunya
二手烟暴露（SSE）与致癌，氧化和炎症反应有关。在此，我们调查是否过早皮肤老化可以诱导SSE在大鼠模型中，并评估高迁移率族蛋白1（HMGB1）蛋白的细胞质易位和皮肤组织中的胶原损失。动物分为两组：SSE和对照组。进行12周的全身SSE。收集背部皮肤组织标本进行HMGB1和马洛里氮染料染色。测定血清HMGB1和胶原水平之间的相关性。暴露于二手烟的大鼠皮肤真皮乳头层胶原纤维束丢失，胶原明显减少（p
Secondhand cigarette smoke exposure (SSE) has been linked to carcinogenic, oxidative, and inflammatory reactions. Herein, we investigated whether premature skin aging could be induced by SSE in a rat model, and assessed the cytoplasmic translocation of high mobility group box 1 (HMGB1) protein and collagen loss in skin tissues. Animals were divided into two groups: SSE and controls. Whole body SSE was carried out for 12 weeks. Dorsal skin tissue specimens were harvested for HMGB1 and Mallory's azan staining. Correlations between serum HMGB1 and collagen levels were determined. Rat skin exposed to secondhand smoke lost collagen bundles in the papillary dermis and collagen decreased significantly (p