Universal Influenza Vaccines: To Dream the Possible Dream?
Universal Influenza Vaccines: To Dream the Possible Dream?
复制标题
通用流感疫苗：实现可能的梦想？
DOI：
10.1021/acsinfecdis.5b00146
复制
发表时间：
2016
影响因子：
5.3
通讯作者：
Taubenberger,JefferyK
中科院分区：
文献类型：
--
作者：
Park,Jae-Keun;Taubenberger,JefferyK
流感病毒是一个重大的公共卫生威胁，造成每年流行的流行病和不可预测的大流行。接种疫苗是控制个别流感病例的最佳手段，也是减少流行病在人群中传播的最佳手段。然而，流感病毒的快速进化需要针对每年的流感流行不断地重新配制疫苗，并且由于大流行无法准确预测，因此目前没有疫苗策略可以诱导针对流感病毒所有亚型的广泛保护。最近的工作表明，这种广泛保护性或“通用”的流感病毒疫苗可能使用靶向保守的B-和T-细胞表位的疫苗策略来实现。
Influenza viruses are a significant public health threat, causing both annually circulating epidemics and unpredictable pandemics. Vaccination is the best means of control against individual cases of influenza and also for decreasing epidemic spread in the population. However, rapid influenza virus evolution requires continual reformulation of vaccines for annual influenza epidemics, and because pandemics cannot be accurately predicted, no current vaccine strategy can induce broad protection against all subtypes of influenza viruses. Recent work has suggested that such broadly protective, or “universal”, influenza virus vaccines might be achievable using vaccine strategies that target conserved B- and T-cell epitopes.