Characterization of patient specific signaling via augmentation of Bayesian networks with disease and patient state nodes.
Characterization of patient specific signaling via augmentation of Bayesian networks with disease and patient state nodes.
复制标题
通过使用疾病和患者状态节点增强贝叶斯网络来表征患者特定信号。
DOI：
10.1109/iembs.2009.5332563
复制
发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Plevritis,SylviaK
中科院分区：
文献类型：
--
作者：
Sachs,Karen;Gentles,AndrewJ;Youland,Ryan;Itani,Solomon;Irish,Jonathan;Nolan,GarryP;Plevritis,SylviaK
Characterization of patient-specific disease features at a molecular level is an important emerging field. Patients may be characterized by differences in the level and activity of relevant biomolecules in diseased cells. When high throughput, high dimensional data is available, it becomes possible to characterize differences not only in the level of the biomolecules, but also in the molecular interactions among them. We propose here a novel approach to characterize patient specific signaling, which augments high throughput single cell data with state nodes corresponding to patient and disease states, and learns a Bayesian network based on this data. Features distinguishing individual patients emerge as downstream nodes in the network. We illustrate this approach with a six phospho-protein, 30,000 cell-per-patient dataset characterizing three comparably diagnosed follicular lymphoma, and show that our approach elucidates signaling differences among them.
