The effect of apomorphine administration on smooth pursuit ocular movements in early Parkinsonian patients
The effect of apomorphine administration on smooth pursuit ocular movements in early Parkinsonian patients
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DOI：
10.1016/s1353-8020(02)00015-9
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发表时间：
2003-01-01
影响因子：
4.1
通讯作者：
Rektor, I
中科院分区：
文献类型：
--
作者：
Bares, M;Brázdil, M;Rektor, I
在阿扑吗啡皮下注射 (ASA) 之前和之后，对 21 名未接受左旋多巴治疗的帕金森病 (PD) 患者进行了眼电图 (EOG) 记录。研究了阿扑吗啡对平滑眼球追踪运动 (SPEM) 的影响。对未进行 ASA 程序而接受 SPEM 记录的年龄匹配的健康受试者进行检查，以比较基线 SPEM。 EOG记录用于比较患者组和对照组，并比较患者组内ASA前后的SPEM。两组之间以及 ASA 前后的 SPEM 均存在显着差异。 SPEM 在早期 PD 患者中受到干扰的理论得到了证实。推测水平 SPEM 受多巴胺能控制。 (C) 2002 Elsevier Science Ltd. 保留所有权利。
Electrooculography (EOG) recordings in 21 L-DOPA-naive patients suffering from Parkinson's disease (PD) were made before and after apomorphine subcutaneous administration (ASA). The effect of apomorphine on smooth pursuit eye movements (SPEM) was studied. Age-matched healthy subjects, who underwent SPEM recordings without the ASA procedure, were examined in order to compare baseline SPEM. EOG recordings were used to compare the patient group and the control group, and to compare the SPEM before and after ASA within the patient group. Significant differences in SPEM were found between both groups, as well as in the SPEM before and after ASA. The theory that SPEM is disturbed in early PD patients was confirmed. The dopaminergic control of horizontal SPEM is supposed. (C) 2002 Elsevier Science Ltd. All rights reserved.