Incorporation of Digital Gene Expression Profiling for Cell-of-Origin Determination (Lymph2Cx Testing) into the Routine Work-Up of Diffuse Large B-Cell Lymphoma.
Incorporation of Digital Gene Expression Profiling for Cell-of-Origin Determination (Lymph2Cx Testing) into the Routine Work-Up of Diffuse Large B-Cell Lymphoma.
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DOI：
10.1007/s12308-019-00344-0
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发表时间：
2019-03
影响因子：
0.6
通讯作者：
Rimsza LM
中科院分区：
文献类型：
--
作者：
Robetorye RS;Ramsower CA;Rosenthal AC;Yip TK;Wendel Spiczka AJ;Glinsmann-Gibson BJ;Rimsza LM
弥漫性大B细胞淋巴瘤（DLBCL）代表了一组临床异质性淋巴瘤，根据形态学和免疫表型的相似性将其分类在一起。基因表达谱进一步基于细胞来源（COO）将DLBCL分类为不同的分子亚组，包括Germination Center B细胞型、活化B细胞型和未分类型。DLBCL的COO分配具有重要的生物学和预后意义，以及新兴的治疗意义。在本文中，我们描述了数字基因表达谱测定（Lymph 2Cx）的首次临床验证，以使用福尔马林固定石蜡包埋（FFPE）组织切片在DLBCL的常规检查中进行COO分配，并描述了由美国病理学家学会/临床实验室改进修正案（CAP/CLIA）认证的临床分子诊断实验室前瞻性分析的90例连续DLBCL病例的结果。
Diffuse large B-cell lymphomas (DLBCL) represent a clinically heterogeneous group of lymphomas that are classified together based on similarities in morphology and immunophenotype. Gene expression profiling further classifies DLBCL into distinct molecular subgroups based on cell-of-origin (COO), including Germinal Center B-cell type, Activated B-cell type, and Unclassified type. COO assignment of DLBCL has important biological and prognostic significance, as well as emerging therapeutic implications. Herein, we describe the first clinical validation of a digital gene expression profiling assay (Lymph2Cx) to perform COO assignment in the routine work-up of DLBCL using formalin-fixed paraffin-embedded (FFPE) tissue sections and describe the results of 90 consecutive DLBCL cases analyzed prospectively by a College of American Pathologists/Clinical Laboratory Improvement Amendments (CAP/CLIA)-certified clinical molecular diagnostics laboratory.
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影响因子：
45.3
作者：
Scott, David W.;Mottok, Anja;Gascoyne, Randy D.
通讯作者：
Gascoyne, Randy D.
影响因子：
64.8
作者：
Alizadeh, AA;Eisen, MB;Staudt, LM
通讯作者：
Staudt, LM
DOI：
10.1158/1078-0432.ccr-13-1482
发表时间：
2013-12-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Coutinho R;Clear AJ;Owen A;Wilson A;Matthews J;Lee A;Alvarez R;Gomes da Silva M;Cabeçadas J;Calaminici M;Gribben JG
通讯作者：
Gribben JG
DOI：
10.14694/edbook_am.2015.35.e458
发表时间：
2015-01-01
期刊：
American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting
影响因子：
--
作者：
Scott, David W
通讯作者：
Scott, David W
影响因子：
64.5
作者：
Reddy A;Zhang J;Davis NS;Moffitt AB;Love CL;Waldrop A;Leppa S;Pasanen A;Meriranta L;Karjalainen-Lindsberg ML;Nørgaard P;Pedersen M;Gang AO;Høgdall E;Heavican TB;Lone W;Iqbal J;Qin Q;Li G;Kim SY;Healy J;Richards KL;Fedoriw Y;Bernal-Mizrachi L;Koff JL;Staton AD;Flowers CR;Paltiel O;Goldschmidt N;Calaminici M;Clear A;Gribben J;Nguyen E;Czader MB;Ondrejka SL;Collie A;Hsi ED;Tse E;Au-Yeung RKH;Kwong YL;Srivastava G;Choi WWL;Evens AM;Pilichowska M;Sengar M;Reddy N;Li S;Chadburn A;Gordon LI;Jaffe ES;Levy S;Rempel R;Tzeng T;Happ LE;Dave T;Rajagopalan D;Datta J;Dunson DB;Dave SS
通讯作者：
Dave SS