Solvent Effects in the Crystalline Sponge Method: Importance of Co-solvents for Ordering Absorbed Guests
Solvent Effects in the Crystalline Sponge Method: Importance of Co-solvents for Ordering Absorbed Guests
复制标题
结晶海绵法中的溶剂效应：共溶剂对于订购吸收客体的重要性
DOI：
10.1021/acs.orglett.1c03660
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发表时间：
2021
期刊：
影响因子：
5.2
通讯作者：
Fujita Makoto
中科院分区：
文献类型：
--
作者：
Wada Naoki;Kageyama Ko;Jung Youngcheol;Mitsuhashi Takaaki;Fujita Makoto
在结晶海绵体方法中，使吸附的客体有序化的关键步骤是将客体浸入结晶海绵体的孔中。在这里，我们发现，溶剂的选择是特别重要的顺利客人浸泡和排序。中等极性的溶剂，如酮和酯，我们以前已经避免了客人浸泡过程，有效地促进扩散和客人通过共结晶填充孔隙中的间隙，通过有序的客人。使用这种修改后的协议，我们成功地证明了各种类固醇的结构分析。
In the crystalline sponge method, the crucial step for ordering the absorbed guest is soaking of the guest into the pores of the crystalline sponge. Here, we find that the choice of solvent is particularly important for smooth guest soaking and ordering. Moderately polar solvents, such as ketones and esters, which we have previously avoided for the guest-soaking process, efficiently promote diffusion and guest ordering by filling the gaps in the pores through co-crystallization with the guests. Using this modified protocol, we successfully demonstrate the structural analysis of various steroids.